Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression.

Medical molecular morphology ·Vol. 42 ·No. 2 ·2009-06-00 ·Pages 82-91

Yoshida J, Horiuchi A, Kikuchi N, Hayashi A, Osada R, Ohira S, Shiozawa T, Konishi I

Abstract

Changes in the expression of E-cadherin have been reported to be important in the tumorigenesis and progression of epithelial ovarian carcinoma. To further examine the mechanisms regulating E-cadherin expression in ovarian tumorigenesis, we investigated the immunohistochemical expression of transcriptional repressors for E-cadherin, such as Snail, Slug, SIP1, and Twist, in the ovarian surface epithelium (OSE) and 95 cases of epithelial ovarian tumors. OSE cells were negative for SIP1 and Slug, whereas weak expression of Snail and Twist was observed in 8 (73%) and 3 (27%) cases, respectively. Of 95 ovarian tumors, the expression of Snail, Slug, SIP1, and Twist increased stepwise in benign, borderline, and malignant tumors. Among them, the expression of Snail showed significantly inverse correlation with that of E-cadherin. Regarding the FIGO stage classification, the expressions of Snail and Twist were significantly increased in advanced cases. The prognosis of ovarian carcinoma patients positive for Snail expression was poorer than that of negative patients. Our results indicate that the expression of E-cadherin transcriptional repressors increased with malignancy in ovarian epithelial neoplasms and that the expression of E-cadherin and its negative regulators is altered during ovarian cancer development and peritoneal dissemination.

MeSH Terms

Biomarkers, Tumor/analysis Blotting, Western Cadherins/analysis,metabolism Carcinoma/genetics,metabolism,pathology Disease Progression Female Humans Immunohistochemistry Nerve Tissue Proteins/analysis,metabolism Nuclear Proteins/analysis,metabolism Ovarian Neoplasms/genetics,metabolism,pathology Ovary/chemistry,cytology,pathology RNA-Binding Proteins/analysis,metabolism Repressor Proteins/analysis,metabolism Reverse Transcriptase Polymerase Chain Reaction Snail Family Transcription Factors Transcription Factors/analysis,metabolism Twist-Related Protein 1/analysis,metabolism

Chemicals

Biomarkers, Tumor Cadherins GEMIN2 protein, human Nerve Tissue Proteins Nuclear Proteins RNA-Binding Proteins Repressor Proteins SNAI1 protein, human Snail Family Transcription Factors TWIST1 protein, human Transcription Factors Twist-Related Protein 1

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Yoshida Junko

Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Horiuchi Akiko

Kikuchi Norihiko

Hayashi Akiko

Osada Ryosuke

Ohira Satoshi

Shiozawa Tanri

Konishi Ikuo

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Article Info

Journal

Medical molecular morphology

Abbr.

Med Mol Morphol

ISSN

1860-1480

DOI

10.1007/s00795-008-0436-5

Published

2009-06-00

Epub

2009-00-18

Pages

82-91

Language

English

Region

Japan

NLM ID

101239023

Subset

External Links

PubMed source DOI: 10.1007/s00795-008-0436-5 View journal details

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Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression.

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