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PMID: 19536080 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The cell cycle and acute kidney injury.

Kidney international ·Vol. 76 ·No. 6 ·2009-09-00 ·Pages 604-13

Price PM, Safirstein RL, Megyesi J

Abstract

Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used to control and perhaps to prevent acute kidney injury. This review is written to address the correlation between cellular life and death in kidney tubules, especially in acute kidney injury.

MeSH Terms
Acute Disease Animals Apoptosis Cell Cycle Cyclin-Dependent Kinase Inhibitor p21/physiology Cyclin-Dependent Kinase Inhibitor p27/physiology Cyclin-Dependent Kinases/physiology DNA Damage Humans Kidney/pathology
Chemicals
CDKN1A protein, human Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Price Peter M
Department of Internal Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA. PricePeterM@uams.edu
Safirstein Robert L
Megyesi Judit
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Article Info
Journal
Kidney international
Abbr.
Kidney Int
ISSN
1523-1755
DOI
10.1038/ki.2009.224
Email
pricepeterm@uams.edu
Published
2009-09-00
Epub
2009-00-17
Pages
604-13
Language
English
Region
United States
NLM ID
0323470
PMCID
PMC2782725
Subset
IM
Grants
NIDDK NIH HHS · R01 DK054471 · United States
NIDDK NIH HHS · R01 DK054471-09 · United States
NIDDK NIH HHS · R01-DK-54471 · United States
External Links
PubMed source DOI: 10.1038/ki.2009.224 PMC Full Text View journal details
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