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PMID: 19525103 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.

Current opinion in cell biology ·Vol. 21 ·No. 5 ·2009-10-00 ·Pages 676-83

Tomar A, Schlaepfer DD

Abstract

Focal adhesion (FA) kinase (FAK) is a cytoplasmic protein-tyrosine kinase involved in cytoskeleton remodeling, formation and disassembly of cell adhesion structures, and in the regulation of Rho-family GTPases. Therefore, FAK is widely accepted as an important promoter of directional cell movement. Recent studies have elucidated new molecular connections of FAK in these processes. Specifically, FAK facilitates the localized and cyclic activation of guanine nucleotide exchange factors (GEFs) and GTPases-activating proteins (GAPs). In general, GEFs activate, while GAPs inactivate RhoGTPases. Therefore, FAK is in a unique signaling position to modulate RhoGTPase activity in space and time, thereby affecting various steps (integrin activation, leading edge formation, FA turnover, and trailing edge retraction) needed for efficient directional cell migration.

MeSH Terms
Animals Cell Adhesion Cell Movement Focal Adhesion Protein-Tyrosine Kinases/metabolism GTPase-Activating Proteins/metabolism Guanine Nucleotide Exchange Factors/metabolism Signal Transduction
Chemicals
GTPase-Activating Proteins Guanine Nucleotide Exchange Factors Focal Adhesion Protein-Tyrosine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tomar Alok
Department of Reproductive Medicine, Moores Cancer Center, University of California-San Diego, CA, USA.
Schlaepfer David D
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51 references, click to expand
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2009.05.006
Published
2009-10-00
Epub
2009-00-12
Pages
676-83
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2754589
Subset
IM
Grants
NHLBI NIH HHS · R01 HL093156-01 · United States
NCI NIH HHS · R01 CA102310 · United States
NIGMS NIH HHS · GM 087400 · United States
NHLBI NIH HHS · HL 093156 · United States
NIGMS NIH HHS · R01 GM087400-01 · United States
NIGMS NIH HHS · R01 GM087400 · United States
NCI NIH HHS · R01 CA102310-06 · United States
NCI NIH HHS · CA 102310 · United States
NHLBI NIH HHS · R01 HL093156 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2009.05.006 PMC Full Text View journal details
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