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PMID: 19524503 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Bridging physiology and pathology in AD.

Cell ·Vol. 137 ·No. 6 ·2009-06-12 ·Pages 997-1000

Kim D, Tsai LH

Abstract

The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and Abeta42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.

MeSH Terms

Alzheimer Disease/pathology,physiopathology Amyloid beta-Peptides/metabolism Amyloid beta-Protein Precursor/metabolism Animals Humans Peptide Fragments/metabolism PrPC Proteins/metabolism Receptors, Tumor Necrosis Factor/metabolism

Chemicals

Amyloid beta-Peptides Amyloid beta-Protein Precursor Peptide Fragments PrPC Proteins Receptors, Tumor Necrosis Factor amyloid beta-protein (1-42)

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kim Dohoon

Howard Hughes Medical Institute, MIT Picower Institute for Learning and Memory, Cambridge, MA 02139, USA.

Tsai Li-Huei

Article Info

Journal

Cell

Abbr.

Cell

ISSN

1097-4172

DOI

10.1016/j.cell.2009.05.042

Published

2009-06-12

Pages

997-1000

Language

English

Region

United States

NLM ID

0413066

Subset

Grants

Howard Hughes Medical Institute · United States

External Links

PubMed source DOI: 10.1016/j.cell.2009.05.042 View journal details

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