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PMID: 19506259
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
Starch as a major integrator in the regulation of plant growth.
Proceedings of the National Academy of Sciences of the United States of America
·Vol. 106
·No. 25
·2009-06-23
·Pages 10348-53
Abstract
Rising demand for food and bioenergy makes it imperative to breed for increased crop yield. Vegetative plant growth could be driven by resource acquisition or developmental programs. Metabolite profiling in 94 Arabidopsis accessions revealed that biomass correlates negatively with many metabolites, especially starch. Starch accumulates in the light and is degraded at night to provide a sustained supply of carbon for growth. Multivariate analysis revealed that starch is an integrator of the overall metabolic response. We hypothesized that this reflects variation in a regulatory network that balances growth with the carbon supply. Transcript profiling in 21 accessions revealed coordinated changes of transcripts of more than 70 carbon-regulated genes and identified 2 genes (myo-inositol-1-phosphate synthase, a Kelch-domain protein) whose transcripts correlate with biomass. The impact of allelic variation at these 2 loci was shown by association mapping, identifying them as candidate lead genes with the potential to increase biomass production.
MeSH Terms
Alleles
Arabidopsis/genetics,growth & development,metabolism
Base Sequence
Carbohydrate Metabolism/genetics
Chromosome Mapping
Energy Metabolism/genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Expression Regulation, Plant
Gene Regulatory Networks
Genetic Variation
Least-Squares Analysis
Molecular Sequence Data
Starch/metabolism
Chemicals
Starch
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
Published
2009-06-23
Epub
2009-00-08
Pages
10348-53
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2693182
Subset
IM
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