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PMID: 195001 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice.

The Journal of experimental medicine ·Vol. 146 ·No. 1 ·1977-07-01 ·Pages 271-6

Stockert E, Old LJ

Abstract

Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes occurring during radiation leukemogenesis. Low levels of murine leukemia virus (MuLV)-related antigens are also detected on preleukemic thymocytes. Comparative tests on individual mice show no direct correlation between TL and MuLV antigen expression.

MeSH Terms
Animals Antigens, Neoplasm/analysis Antigens, Viral/analysis Antilymphocyte Serum/analysis Histocompatibility Antigens/analysis Leukemia Virus, Murine/immunology Leukemia, Radiation-Induced/immunology Mice Mice, Inbred C57BL T-Lymphocytes/immunology Thymus Neoplasms/immunology
Chemicals
Antigens, Neoplasm Antigens, Viral Antilymphocyte Serum Histocompatibility Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stockert E
Old L J
References (17)
17 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.146.1.271
Published
1977-07-01
Pages
271-6
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180749
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.146.1.271 PMC Full Text View journal details
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