In vivo loss of telomeric repeats with age in humans.

Mutation research ·Vol. 256 ·No. 1 ·1991-01-00 ·Pages 45-8

Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ

Abstract

Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.

MeSH Terms

Adolescent Adult Aged Aged, 80 and over Aging/genetics Blotting, Southern Child Child, Preschool Chromosomes/physiology Epidermal Cells Humans Infant Infant, Newborn Middle Aged Repetitive Sequences, Nucleic Acid/genetics Telomere/physiology

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Lindsey J

MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K.

McGill N I

Lindsey L A

Green D K

Cooke H J

Article Info

Journal

Mutation research

Abbr.

Mutat Res

ISSN

0027-5107

DOI

10.1016/0921-8734(91)90032-7

Published

1991-01-00

Pages

45-8

Language

English

Region

Netherlands

NLM ID

0400763

Subset

External Links

PubMed source DOI: 10.1016/0921-8734(91)90032-7 View journal details

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In vivo loss of telomeric repeats with age in humans.

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