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PMID: 19420 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Metabolism of 6-aminonicotinic acid in Escherichia coli.

Journal of bacteriology ·Vol. 131 ·No. 3 ·1977-09-00 ·Pages 789-94

Cobb JR, Pearcy SC, Gholson RK

Abstract

A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotide cycle. It is concluded that 6-aminonicotinamide and 6-aminonicotinic acid probably exert at least a portion of their bacteriostatic effects by being metabolized, by the enzymes of the pyridine nucleotide cycle, to 6-aminonicotinamide adenine dinucleotide and 6-aminonicotinamide adenine dinucleotide phosphate. These compounds are not electron acceptors and are known inhibitors of some pyridine nucleotide-linked dehydrogenases.

MeSH Terms
Escherichia coli/metabolism Mutation NAD/analogs & derivatives,biosynthesis NADP/analogs & derivatives,biosynthesis Niacinamide/analogs & derivatives,biosynthesis Nicotinic Acids/metabolism
Chemicals
Nicotinic Acids NAD Niacinamide NADP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cobb J R
Pearcy S C
Gholson R K
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21 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.131.3.789-794.1977
Published
1977-09-00
Pages
789-94
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235532
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.131.3.789-794.1977 PMC Full Text View journal details
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