YB-1 translational control of epithelial-mesenchyme transition.

Cancer cell ·Vol. 15 ·No. 5 ·2009-05-05 ·Pages 357-9

Mouneimne G, Brugge JS

Abstract

Transitions between epithelial and mesenchmal phenotypes play critical roles in normal development and cancer progression. In this issue of Cancer Cell, Evdokimova et al. demonstrate that YB-1 regulates epithelial-mesenchyme transition (EMT) by inducing cap-independent translation of mRNAs encoding EMT-promoting factors and suppressing cap-dependent translation of mRNAs encoding growth-promoting factors.

MeSH Terms

Cell Differentiation/physiology DNA-Binding Proteins/physiology Epithelial Cells/cytology,physiology Humans Mesoderm/cytology,physiology Nuclear Proteins/physiology Protein Biosynthesis RNA Caps/physiology RNA, Messenger/physiology Snail Family Transcription Factors Transcription Factors/physiology Y-Box-Binding Protein 1

Chemicals

DNA-Binding Proteins Nuclear Proteins RNA Caps RNA, Messenger Snail Family Transcription Factors Transcription Factors Y-Box-Binding Protein 1 YBX1 protein, human

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mouneimne Ghassan

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Brugge Joan S

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1878-3686

DOI

10.1016/j.ccr.2009.04.006

Published

2009-05-05

Pages

357-9

Language

English

Region

United States

NLM ID

101130617

Subset

Corrections

CommentOn

PMID: 19411069

External Links

PubMed source DOI: 10.1016/j.ccr.2009.04.006 View journal details

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YB-1 translational control of epithelial-mesenchyme transition.

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