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PMID: 194055 Published · ppublish English Journal Article

Expression of tumor-specific transplantation antigen in cell lines transformed by wild-type of tsA mutant simian virus 40.

Journal of virology ·Vol. 22 ·No. 2 ·1977-05-00 ·Pages 281-9

Chang C, Anderson JL, Martin RG, Mora PT

Abstract

The simian virus 40-induced tumor-specific surface antigen(s) (TSSA) and tumor-specific transplantation antigen(s) (TSTA)were detected in cells transformed by wild-type or temperature-sensitive mutant simian virus 40 by an antibody-mediated cytolytic assay for TSSA and an immunization test for TSTA. Cells transformed by tsA mutants, which lose their transformed phenotype when grown at nonpermissive temperatures, nonetheless do express TSSA and TSTA as well as T-antigen at both temperatures.

MeSH Terms
Animals Antigens, Neoplasm/analysis Cell Line Cell Membrane/immunology Cell Transformation, Neoplastic Cricetinae Cytotoxicity Tests, Immunologic Histocompatibility Antigens/analysis Immunization Mice Mutation Neoplasms, Experimental/prevention & control Phenotype Simian virus 40/growth & development Temperature
Chemicals
Antigens, Neoplasm Histocompatibility Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Chang C
Anderson J L
Martin R G
Mora P T
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36 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.22.2.281-289.1977
Published
1977-05-00
Pages
281-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC515717
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.22.2.281-289.1977 PMC Full Text View journal details
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