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PMID: 19357639 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tissue specificity and the human protein interaction network.

Molecular systems biology ·Vol. 5 ·2009-00-00 ·Pages 260

Bossi A, Lehner B

Abstract

A protein interaction network describes a set of physical associations that can occur between proteins. However, within any particular cell or tissue only a subset of proteins is expressed and so only a subset of interactions can occur. Integrating interaction and expression data, we analyze here this interplay between protein expression and physical interactions in humans. Proteins only expressed in restricted cell types, like recently evolved proteins, make few physical interactions. Most tissue-specific proteins do, however, bind to universally expressed proteins, and so can function by recruiting or modifying core cellular processes. Conversely, most 'housekeeping' proteins that are expressed in all cells also make highly tissue-specific protein interactions. These results suggest a model for the evolution of tissue-specific biology, and show that most, and possibly all, 'housekeeping' proteins actually have important tissue-specific molecular interactions.

MeSH Terms
Databases, Protein Evolution, Molecular Humans Organ Specificity Protein Binding Proteins/metabolism
Chemicals
Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bossi Alice
EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, UPF, Barcelona, Spain.
Lehner Ben
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Article Info
Journal
Molecular systems biology
Abbr.
Mol Syst Biol
ISSN
1744-4292
DOI
10.1038/msb.2009.17
Published
2009-00-00
Epub
2009-00-07
Pages
260
Language
English
Region
England
NLM ID
101235389
PMCID
PMC2683721
Subset
IM
External Links
PubMed source DOI: 10.1038/msb.2009.17 PMC Full Text View journal details
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