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PMID: 19342592 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Use-dependent plasticity in clock neurons regulates sleep need in Drosophila.

Science (New York, N.Y.) ·Vol. 324 ·No. 5923 ·2009-04-03 ·Pages 105-8

Donlea JM, Ramanan N, Shaw PJ

Abstract

Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleep need. Flies increase sleep both after exposure to an enriched social environment and after protocols that induce long-term memory. We found that flies mutant for rutabaga, period, and blistered were deficient for experience-dependent increases in sleep. Rescue of each of these genes within the ventral lateral neurons (LNVs) restores increased sleep after social enrichment. Social experiences that induce increased sleep were associated with an increase in the number of synaptic terminals in the LNV projections into the medulla. The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation.

MeSH Terms
Adenylyl Cyclases/genetics,physiology Animals Biological Clocks/genetics Brain/physiology Circadian Rhythm/genetics Drosophila Proteins/genetics,metabolism,physiology Drosophila melanogaster/cytology,genetics,physiology ErbB Receptors/genetics,metabolism Female Genes, Insect Male Memory Models, Animal Mutation Neuronal Plasticity Neurons/physiology,ultrastructure Nuclear Proteins/genetics,physiology Period Circadian Proteins Presynaptic Terminals/physiology,ultrastructure Receptors, Invertebrate Peptide/genetics,metabolism Serum Response Factor/genetics,physiology Sleep/physiology Sleep Deprivation Social Behavior Synapses/physiology
Chemicals
Drosophila Proteins Nuclear Proteins PER protein, Drosophila Period Circadian Proteins Receptors, Invertebrate Peptide Serum Response Factor bs protein, Drosophila Egfr protein, Drosophila ErbB Receptors Adenylyl Cyclases Rut protein, Drosophila
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Donlea Jeffrey M
Department of Anatomy and Neurobiology, Washington University in St. Louis, 660 South Euclid Avenue, St. Louis, Missouri, USA.
Ramanan Narendrakumar
Shaw Paul J
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1166657
Published
2009-04-03
Pages
105-8
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2850598
Subset
IM
Grants
NIGMS NIH HHS · T32 GM008151 · United States
NIGMS NIH HHS · T32-GM008151 · United States
NINDS NIH HHS · F31 NS063514 · United States
NINDS NIH HHS · F31 NS063514-01A1 · United States
NINDS NIH HHS · R01-NS051305-01A1 · United States
NINDS NIH HHS · R01 NS051305 · United States
Corrections
CommentIn
PMID: 19342557
External Links
PubMed source DOI: 10.1126/science.1166657 PMC Full Text View journal details
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