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PMID: 19339974 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy.

Nature reviews. Neuroscience ·Vol. 10 ·No. 5 ·2009-05-00 ·Pages 333-44

Bu G

Abstract

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is probably influenced by both genetic and environmental risk factors. A strong genetic risk factor for late-onset AD is the presence of the epsilon4 allele of the apolipoprotein E (APOE) gene, which encodes a protein with crucial roles in cholesterol metabolism. There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-beta peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors. Emerging knowledge of the contribution of APOE to the pathophysiology of AD presents new opportunities for AD therapy.

MeSH Terms
Alzheimer Disease/etiology,genetics,therapy Animals Apolipoproteins E/genetics,metabolism Humans Low Density Lipoprotein Receptor-Related Protein-1/genetics,metabolism Signal Transduction/physiology
Chemicals
Apolipoproteins E Low Density Lipoprotein Receptor-Related Protein-1
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bu Guojun
Hope Center for Neurological Disorders, Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. bu@wustl.edu
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-0048
DOI
10.1038/nrn2620
Email
bu@wustl.edu
Published
2009-05-00
Epub
2009-00-02
Pages
333-44
Language
English
Region
England
NLM ID
100962781
PMCID
PMC2908393
Subset
IM
Grants
NIA NIH HHS · R01 AG027924-01 · United States
NIA NIH HHS · R01AG027924 · United States
NIA NIH HHS · P01 AG030128-01A28715 · United States
NIA NIH HHS · R01 AG027924-04 · United States
NIA NIH HHS · R01 AG031784 · United States
NIA NIH HHS · R01 AG027924-03 · United States
NIA NIH HHS · R01 AG027924-03S1 · United States
NIA NIH HHS · P01 AG030128-01A28719 · United States
NIA NIH HHS · R01 AG027924-05 · United States
NIA NIH HHS · R01 AG027924-02 · United States
NIA NIH HHS · R01 AG031784-01 · United States
NIA NIH HHS · R01 AG027924 · United States
NIA NIH HHS · P01 AG030128 · United States
NIA NIH HHS · R01AG031784 · United States
NIA NIH HHS · R01 AG031784-02 · United States
External Links
PubMed source DOI: 10.1038/nrn2620 PMC Full Text View journal details
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