Type 1 diabetes genes in rats: few or many?

Diabetes ·Vol. 58 ·No. 4 ·2009-04-00 ·Pages 796-7

Leiter EH

Abstract

暂无摘要

MeSH Terms

Animals Diabetes Mellitus, Type 1/genetics Disease Models, Animal Genes, MHC Class II/genetics Humans Major Histocompatibility Complex/genetics Mice Mice, Inbred NOD/genetics Models, Genetic Rats/genetics

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Leiter Edward H

The Jackson Laboratory, Bar Harbor, Maine, USA. ehl@jax.org

References (9)

9 references, click to expand

Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.
Biochem Soc Trans. 2008 Jun;36(Pt 3):312-5 PMID: 18481948
Type 1 diabetes in the BB rat: a polygenic disease.
Diabetes. 2009 Apr;58(4):1007-17 PMID: 19168599
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 2002 Aug;31(4):391-4 PMID: 12118252
Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses.
Mamm Genome. 1992;3(8):457-60 PMID: 1643308
Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
Nature. 1991 Jun 13;351(6327):542-7 PMID: 1675432
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
Nat Genet. 2007 Jul;39(7):857-64 PMID: 17554260
Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.
Mamm Genome. 2005 Jun;16(6):432-41 PMID: 16075370
Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.
Diabetes. 1992 Dec;41(12):1617-23 PMID: 1446803
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
ILAR J. 2004;45(3):278-91 PMID: 15229375

Article Info

Journal

Diabetes

Abbr.

Diabetes

ISSN

1939-327X

DOI

10.2337/db08-1811

ehl@jax.org

Published

2009-04-00

Pages

796-7

Language

English

Region

United States

NLM ID

0372763

PMCID

PMC2661579

Subset

Corrections

CommentOn

PMID: 19168599

External Links

PubMed source DOI: 10.2337/db08-1811 PMC Full Text View journal details

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Type 1 diabetes genes in rats: few or many?

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