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PMID: 193191 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Synapse formation between two clonal cell lines.

Science (New York, N.Y.) ·Vol. 196 ·No. 4293 ·1977-05-27 ·Pages 995-8

Christian CN, Nelson PG, Peacock J, Nirenberg M

Abstract

Clonal neuroblastoma x glioma hybrid cells frequently formed synapses with clonal mouse striated muscle cells. Clonal myotubes were similar to cultured mouse embryo myotubes with respect to acetylcholine sensitivity and other membrane properties examined. However, acetylcholine sensitivity measurements indicate that acetylcholine receptors of clonal myotubes are distributed more uniformly over the cell surface than the receptors of cultured mouse embryo myotubes.

MeSH Terms

Acetylcholine/pharmacology Action Potentials/drug effects Cell Line Clone Cells Electric Conductivity Glioma Hybrid Cells Membrane Potentials Muscles Neuroblastoma Neuromuscular Junction/physiology Neurons/physiology Receptors, Cholinergic/physiology Spinal Cord/physiology Synapses/physiology Synaptic Transmission/drug effects

Chemicals

Receptors, Cholinergic Acetylcholine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Christian C N

Nelson P G

Peacock J

Nirenberg M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.193191

Published

1977-05-27

Pages

995-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.193191 View journal details

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