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PMID: 19307370 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus.

Antimicrobial agents and chemotherapy ·Vol. 53 ·No. 6 ·2009-06-00 ·Pages 2654-6

Zarember KA, Cruz AR, Huang CY, Gallin JI

Abstract

Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.

MeSH Terms

Amphotericin B/pharmacology Antifungal Agents/pharmacology Aspergillus fumigatus/drug effects Ciclopirox Deferiprone Drug Combinations Fluconazole/pharmacology Iron Chelating Agents/pharmacology Ketoconazole/pharmacology Microbial Sensitivity Tests Pyridones/pharmacology

Chemicals

Antifungal Agents Drug Combinations Iron Chelating Agents Pyridones Ciclopirox Deferiprone Amphotericin B Fluconazole Ketoconazole

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Zarember Kol A

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1456, USA. kzarember@niaid.nih.gov

Cruz Anna R

Huang Chiung-Yu

Gallin John I

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

1098-6596

DOI

10.1128/AAC.01547-08

kzarember@niaid.nih.gov

Published

2009-06-00

Epub

2009-00-23

Pages

2654-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC2687209

Subset

Grants

Intramural NIH HHS · United States

External Links

PubMed source DOI: 10.1128/AAC.01547-08 PMC Full Text View journal details

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Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus.

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