| GeneLibs

题目:: Follicular helper T cells: lineage and location.
作者:: Fazilleau(Nicolas),Mark(Linda),McHeyzer-Williams(Louise J),McHeyzer-Williams(Michael G)
状态:: 发布时间2009-03-23 , 更新时间 2016-11-22
期刊:: Immunity
摘要:: Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function. Here, we review recent advances that have helped to unravel distinctive elements of developmental programming for Tfh cells and unique effector Tfh cell functions focused on antigen-primed B cells. Understanding the regulatory functions of Tfh cells in the germinal center and the subsequent regulation of memory B cell responses to antigen recall represent the frontiers of this research area with the potential to alter fundamentally the design of future vaccines.
语言:: eng
DOI:

文献库文献相关信息