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PMID: 19287449 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Principles of c-di-GMP signalling in bacteria.

Nature reviews. Microbiology ·Vol. 7 ·No. 4 ·2009-04-00 ·Pages 263-73

Hengge R

Abstract

On the stage of bacterial signal transduction and regulation, bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has long played the part of Sleeping Beauty. c-di-GMP was first described in 1987, but only recently was it recognized that the enzymes that 'make and break' it are not only ubiquitous in the bacterial world, but are found in many species in huge numbers. As a key player in the decision between the motile planktonic and sedentary biofilm-associated bacterial 'lifestyles', c-di-GMP binds to an unprecedented range of effector components and controls diverse targets, including transcription, the activities of enzymes and larger cellular structures. This Review focuses on emerging principles of c-di-GMP signalling using selected systems in different bacteria as examples.

MeSH Terms
Bacteria/metabolism Cyclic GMP/analogs & derivatives,metabolism Escherichia coli Proteins Phosphoric Diester Hydrolases/metabolism Phosphorus-Oxygen Lyases/metabolism Signal Transduction
Chemicals
Escherichia coli Proteins bis(3',5')-cyclic diguanylic acid Phosphoric Diester Hydrolases Phosphorus-Oxygen Lyases diguanylate cyclase Cyclic GMP
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hengge Regine
Institut für Biologie-Mikrobiologie, Freie Universität Berlin, 14195 Berlin, Germany. Rhenggea@zedat.fu-berlin.de
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro2109
Email
rhenggea@zedat.fu-berlin.de
Published
2009-04-00
Pages
263-73
Language
English
Region
England
NLM ID
101190261
Subset
IM
External Links
PubMed source DOI: 10.1038/nrmicro2109 View journal details
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