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题目:: Activated T cells inhibit NK cell-mediated tumour rejection.
作者:: Wang(X-J),Hu(J),Yuan(J),Peng(Y-M),Gui(L),He(W-F),Tan(J),Luo(G-X),Wu(J)
状态:: 发布时间2009-03-16 , 更新时间 2009-03-16
期刊:: Scand J Immunol
摘要:: Previous studies have described the regulation of some T-cell subsets toward natural killer (NK) cells. Naturally occurring CD4(+)CD25(+) T regulatory cells can inhibit NK cell cytotoxicity, while activated interleukin-2 (IL-2) secreting T cells can stimulate NK cells. However, little is known about the impact of the integrity T-cell population on the final outcome of NK cell cytotoxicity. We thus examined the possible role of activated T cells in affecting NK cell cytotoxicity by mixed lymphocyte co-cultures in vitro and a B16 melanoma tumour model in vivo. In our study, activated T cells were found to be able to significantly inhibit NK cell cytotoxicity in vitro and blunt NK cell-mediated tumour rejection in vivo. The inhibition of NK cell function is a cell-cell contact dependent way. Results suggest that activated T cells may play an important role in limiting NK cell functions, which might be very significant for the design of biotherapy against tumour or infection in future.
语言:: eng
DOI:: 10.1111/j.1365-3083.2009.02227.x

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