| GeneLibs

题目:: Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
作者:: Sehl(Mary E),Langer(Lucy R),Papp(Jeanette C),Kwan(Lorna),Seldon(Joyce L),Arellano(Geovanni),Reiss(Jean),Reed(Elaine F),Dandekar(Sugandha),Korin(Yael),Sinsheimer(Janet S),Zhang(Zuo-Feng),Ganz(Patricia A)
状态:: 发布时间2009-03-17 , 更新时间 2016-11-22
期刊:: Clin Cancer Res
摘要:: DNA damage recognition and repair play a major role in risk for breast cancer. We investigated 104 single nucleotide polymorphisms (SNP) in 17 genes whose protein products are involved in double-stranded break repair (DSBR).,We used a case-control design. Both the case individuals affected with breast cancer or with both breast and ovarian cancers and the controls had similar familial risk of breast cancer and were participants in a high-risk cancer registry.,We found that 12 of the polymorphisms are associated with breast or breast and ovarian cancers, most notably rs16888927, rs16888997, and rs16889040, found in introns of RAD21, suggesting that SNPs in other genes in the DSBR pathway in addition to BRCA1 and BRCA2 may affect breast cancer risk.,SNPs within or near several DSBR DNA repair pathway genes are associated with breast cancer in individuals from a high-risk population. In addition, our study reemphasizes the unique perspective that recruitment of cases and controls from family cancer registries has for gene discovery studies.
语言:: eng
DOI:

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息