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PMID: 19261329 Published · ppublish English Clinical Trial, Phase II Journal Article Research Support, N.I.H., Extramural

Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma.

Leukemia research ·Vol. 33 ·No. 11 ·2009-11-00 ·Pages 1475-80

Farag SS, Zhang S, Jansak BS, Wang X, Kraut E, Chan K, Dancey JE, Grever MR

Abstract

In a phase II trial, 16 patients with relapsed refractory multiple myeloma received temsirolimus 25mg I.V. weekly until progression. One partial response and 5 minor responses were observed for a total response rate of 38%. The median time to progression was 138 days. Grade 3-4 toxicity included fatigue (n=3), neutropenia (n=2), thrombocytopenia (n=2), interstitial pneumonitis (n=1), stomatitis (n=1) and diarrhea (n=1). Clinical activity was associated with a higher area under the curve (AUC) and maximal reduction in phosphorylated p70(S6)K and 4EBP1 in peripheral blood mononuclear cells. At the dose and schedule used, temsirolimus had low single agent activity. Investigation of alternate dosing schedules and use in combinations is indicated.

MeSH Terms
Adult Aged Antineoplastic Agents/adverse effects,pharmacokinetics,therapeutic use Female Humans Male Middle Aged Multiple Myeloma/drug therapy Recurrence Sirolimus/adverse effects,analogs & derivatives,pharmacokinetics,therapeutic use
Chemicals
Antineoplastic Agents temsirolimus Sirolimus
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Farag Sherif S
Departments of Internal Medicine and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States. ssfarag@iupui.edu
Zhang Shuhong
Jansak Buffy S
Wang Xiaojing
Kraut Eric
Chan Kenneth
Dancey Janet E
Grever Michael R
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Article Info
Journal
Leukemia research
Abbr.
Leuk Res
ISSN
1873-5835
Published
2009-11-00
Epub
2009-00-03
Pages
1475-80
Language
English
Region
England
NLM ID
7706787
PMCID
PMC3771631
Subset
IM
Grants
NCI NIH HHS · R21 CA112894 · United States
NCI NIH HHS · R21 CA112894-02 · United States
NCI NIH HHS · R21 CA11289 · United States
NCI NIH HHS · UO1 CA76576 · United States
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