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PMID: 1924380 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Antigenic variation in Plasmodium falciparum.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 20 ·1991-10-15 ·Pages 9171-4

Biggs BA, Goozé L, Wycherley K, Wollish W, Southwell B, Leech JH, Brown GV

Abstract

Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of erythrocyte surface antigens. A cloned line of P. falciparum gave rise to progeny that expressed antigenically distinct forms of an erythrocyte surface antigen but were otherwise identical. This demonstrates that antigenic differences on the surface of P. falciparum-infected erythrocytes can arise by antigenic variation of clonal parasite populations. The antigenic differences were shown to result from antigenic variation of the parasite-encoded protein, the P. falciparum erythrocyte membrane protein 1.

MeSH Terms
Agglutination Animals Antigenic Variation Antigens, Protozoan/analysis,genetics,immunology Blotting, Western Erythrocytes/physiology Humans Immune Sera Immunoblotting Plasmodium falciparum/genetics,immunology Rabbits
Chemicals
Antigens, Protozoan Immune Sera
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Biggs B A
Immunoparasitology Unit, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Goozé L
Wycherley K
Wollish W
Southwell B
Leech J H
Brown G V
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.20.9171
Published
1991-10-15
Pages
9171-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52674
Subset
IM
Grants
NIGMS NIH HHS · 5 T32 GM07546 · United States
External Links
PubMed source DOI: 10.1073/pnas.88.20.9171 PMC Full Text View journal details
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