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PMID: 19238148 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cell cycle, CDKs and cancer: a changing paradigm.

Nature reviews. Cancer ·Vol. 9 ·No. 3 ·2009-03-00 ·Pages 153-66

Malumbres M, Barbacid M

Abstract

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.

MeSH Terms
Animals Cell Cycle Cell Proliferation Chromosomal Instability Chromosome Aberrations Cyclin D Cyclin E/physiology Cyclin-Dependent Kinases/antagonists & inhibitors,physiology Cyclins/physiology DNA Damage Humans Mitosis Neoplasms/drug therapy,genetics,pathology Neoplastic Stem Cells/cytology Protein Kinase Inhibitors/therapeutic use
Chemicals
Cyclin D Cyclin E Cyclins Protein Kinase Inhibitors Cyclin-Dependent Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Malumbres Marcos
Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.
Barbacid Mariano
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2602
Published
2009-03-00
Pages
153-66
Language
English
Region
England
NLM ID
101124168
Subset
IM
Grants
Worldwide Cancer Research · 08-0188 · United Kingdom
Databases
ClinicalTrials.gov
NCT00141297, NCT00147485, NCT00292864, NCT00372073, NCT00390117, NCT00400296, NCT00407498, NCT00446342, NCT00772876
External Links
PubMed source DOI: 10.1038/nrc2602 View journal details
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