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PMID: 19230040 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Epidemiology and gene markers of ulcerative colitis in the Chinese.

World journal of gastroenterology ·Vol. 15 ·No. 7 ·2009-02-21 ·Pages 788-803

Yun J, Xu CT, Pan BR

Abstract

Inflammatory bowel disease (IBD) includes two similar yet distinct conditions called ulcerative colitis (UC) and Crohn's disease (CD). These diseases affect the digestive system and cause the inflammation of intestinal tissue, form sores and bleed easily. Most children with IBD are diagnosed in late childhood and adolescence. However, both UC and CD have been reported as early as in infancy. Most information pertaining to the epidemiology of IBD is based upon adult studies. Symptoms include abdominal pain, cramping, fatigue and diarrhea. Genetic factors play a significant role in determining IBD susceptibility. Epidemiological data support a genetic contribution to the pathogenesis of IBD. Recently, numerous new genes have been identified as being involved in the genetic susceptibility to IBD: TNF-308A, CARD15 (NOD2), MIF-173, N-acetyltransferase 2 (NAT2), NKG2D (natural killer cell 2D), STAT6 (signal transducer and activator of transcription 6), CTLA-4 (cytotoxic T lymphocyte antigen-4), MICA-MICB (major histocompatibility complex A and B), HLA-DRB1, HLA class-II, IL-18, IL-4, MICA-A5, CD14, TLR4, Fas-670, p53 and NF-kappaB. The characterization of these novel genes has the potential to identify therapeutic agents and aid clinical assessment of phenotype and prognosis in patients with IBD (UC and CD).

MeSH Terms
Adolescent Adult Aged Child China/epidemiology Colitis, Ulcerative/epidemiology,genetics,immunology Crohn Disease/epidemiology,genetics Female Genetic Markers Genetic Predisposition to Disease HLA-D Antigens/genetics Humans Infant Inflammatory Bowel Diseases/epidemiology,genetics Lymphokines/genetics Male Middle Aged Nod2 Signaling Adaptor Protein/genetics Tumor Necrosis Factor-alpha/genetics
Chemicals
Genetic Markers HLA-D Antigens Lymphokines NOD2 protein, human Nod2 Signaling Adaptor Protein Tumor Necrosis Factor-alpha
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yun Jun
Department of General Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Xu Chang-Tai
Pan Bo-Rong
References (49)
49 references, click to expand
  1. Distribution of signal transducer and activator of transcription 6 gene G2964A polymorphism in Chinese patients with ulcerative colitis.
    J Gastroenterol Hepatol. 2006 Dec;21(12):1854-7 PMID: 17074026
  2. Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients.
    Inflamm Bowel Dis. 2006 May;12(5):369-73 PMID: 16670525
  3. [Indications for colonoscopy examination and its disease distribution: a report of 5690 cases].
    Zhonghua Wei Chang Wai Ke Za Zhi. 2006 May;9(3):214-6 PMID: 16721680
  4. MHC class I chain-related gene A-A5.1 allele is associated with ulcerative colitis in Chinese population.
    Clin Exp Immunol. 2005 Oct;142(1):193-8 PMID: 16178876
  5. [Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis].
    Zhonghua Nei Ke Za Zhi. 2006 Jun;45(6):478-81 PMID: 16831326
  6. Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease.
    Clin Exp Immunol. 2003 Mar;131(3):446-50 PMID: 12605697
  7. [Association between the cytotoxic T lymphocyte antigen-4 gene microsatellite polymorphism and inflammatory bowel diseases in the Chinese].
    Zhonghua Nei Ke Za Zhi. 2004 Mar;43(3):191-4 PMID: 15059373
  8. MICB microsatellite polymorphism is associated with ulcerative colitis in Chinese population.
    Clin Immunol. 2006 Aug;120(2):199-204 PMID: 16679067
  9. [The effects of anti-inflammatory on activation of nuclear factor-kappaB and expression of cell adhesion molecules in patients with ulcerative colitis].
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2004 Oct;21(5):732-6 PMID: 15553846
  10. N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease.
    Can J Gastroenterol. 2007 Mar;21(3):155-8 PMID: 17377643
  11. Association of HLA class-II genes and anti-neutrophil cytoplasmic antibodies in Chinese patients with inflammatory bowel disease.
    Scand J Gastroenterol. 1998 Jun;33(6):623-7 PMID: 9669635
  12. [Alterations of p53 gene and microsatellite instability in ulcerative colitis and ulcerative colitis-associated colorectal cancer].
    Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Mar;33(2):108-14 PMID: 15067728
  13. Cellular and molecular immunopathogenesis of ulcerative colitis.
    Cell Mol Immunol. 2006 Feb;3(1):35-40 PMID: 16549047
  14. Novel genetic markers in inflammatory bowel disease.
    World J Gastroenterol. 2007 Nov 14;13(42):5560-70 PMID: 17948929
  15. Ulcerative colitis: diagnosis and management.
    BMJ. 2006 Aug 12;333(7563):340-3 PMID: 16902215
  16. OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.
    World J Gastroenterol. 2008 Aug 21;14(31):4923-7 PMID: 18756601
  17. The role of genetics in inflammatory bowel disease.
    Curr Drug Targets. 2008 May;9(5):361-8 PMID: 18473763
  18. [The relationship of nature killer cell 2D gene polymorphisms and ulcerative colitis in the Chinese].
    Zhonghua Nei Ke Za Zhi. 2006 Oct;45(10):824-6 PMID: 17217747
  19. Basic research on inflammatory bowel disease in China.
    J Dig Dis. 2007 Nov;8(4):194-7 PMID: 17970875
  20. [Activation of nuclear factor-kappaB and its relationship with cytokine gene expression in colonic mucosa of ulcerative colitis patients].
    Zhonghua Nei Ke Za Zhi. 2002 Apr;41(4):252-5 PMID: 12133438
  21. [Interleukin (IL)-1beta, IL-1 receptor antagonist and IL-4 gene polymorphisms in ulcerative colitis in the Chinese].
    Zhonghua Nei Ke Za Zhi. 2002 Apr;41(4):248-51 PMID: 12133437
  22. Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis.
    J Gastroenterol Hepatol. 2006 Feb;21(2):449-53 PMID: 16509873
  23. Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively.
    Immunogenetics. 2002 Mar;53(12):1020-7 PMID: 11904678
  24. Ulcerative colitis in China: retrospective analysis of 3100 hospitalized patients.
    J Gastroenterol Hepatol. 2007 Sep;22(9):1450-5 PMID: 17716349
  25. Risk factors for ulcerative colitis in a Chinese population: an age-matched and sex-matched case-control study.
    J Clin Gastroenterol. 2007 Mar;41(3):280-4 PMID: 17426467
  26. Epidemiology and clinical characteristics of ulcerative colitis in Chinese population: experience from a single center in Hong Kong.
    J Gastroenterol Hepatol. 2008 Mar;23(3):406-10 PMID: 17623033
  27. Inflammatory bowel disease: progress toward a gene.
    Can J Gastroenterol. 2000 Mar;14(3):207-18 PMID: 10758418
  28. Clinical presentation of inflammatory bowel disease: a hospital based retrospective study of 379 patients in eastern China.
    Chin Med J (Engl). 2005 May 5;118(9):747-52 PMID: 15899137
  29. Retrospective survey of 452 patients with inflammatory bowel disease in Wuhan city, central China.
    Inflamm Bowel Dis. 2006 Mar;12(3):212-7 PMID: 16534423
  30. Drug therapy for ulcerative colitis.
    World J Gastroenterol. 2004 Aug 15;10(16):2311-7 PMID: 15285010
  31. NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality.
    World J Gastroenterol. 2004 Apr 1;10(7):1069-71 PMID: 15052696
  32. Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients.
    Postgrad Med J. 2005 Aug;81(958):526-9 PMID: 16085746
  33. Interleukin-18 genetics and inflammatory disease susceptibility.
    Genes Immun. 2007 Mar;8(2):91-9 PMID: 17215860
  34. [NOD2/CARD15 gene polymorphisms and susceptibility to Crohn's disease in Chinese Han population].
    Zhonghua Nei Ke Za Zhi. 2005 Mar;44(3):210-2 PMID: 15840263
  35. MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes.
    Exp Mol Pathol. 2008 Aug;85(1):40-4 PMID: 18547561
  36. CTLA-4 gene polymorphisms in Chinese patients with ulcerative colitis.
    Inflamm Bowel Dis. 2005 Jul;11(7):653-6 PMID: 15973119
  37. An analysis of 10218 ulcerative colitis cases in China.
    World J Gastroenterol. 2002 Feb;8(1):158-61 PMID: 11833094
  38. Association of MIF-173 gene polymorphism with inflammatory bowel disease in Chinese Han population.
    Cytokine. 2008 Jan;41(1):44-7 PMID: 18054247
  39. Association of Fas-670 gene polymorphism with inflammatory bowel disease in Chinese patients.
    World J Gastroenterol. 2005 Jan 21;11(3):415-7 PMID: 15637757
  40. CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease.
    Scand J Gastroenterol. 2002 Nov;37(11):1296-300 PMID: 12465728
  41. Correlation between a gene polymorphism of tumor necrosis factor and inflammatory bowel disease.
    Chin J Dig Dis. 2005;6(4):170-4 PMID: 16246225
  42. Polymorphism of HLA-DRB1 gene shows no strong association with ulcerative colitis in Chinese patients.
    Int J Immunogenet. 2006 Feb;33(1):37-40 PMID: 16426241
  43. Genes, diet and inflammatory bowel disease.
    Mutat Res. 2007 Sep 1;622(1-2):70-83 PMID: 17628615
  44. Effect of environmental substances on the activity of arylamine N-acetyltransferases.
    Curr Drug Metab. 2008 Jul;9(6):505-9 PMID: 18680470
  45. [Mucin core peptide expression in malignant and non-malignant colorectal tissues].
    Zhonghua Zhong Liu Za Zhi. 1992 Jul;14(4):267-9 PMID: 1327701
  46. Genetic susceptibility to ulcerative colitis in the Chinese Han ethnic population: association with TNF polymorphisms.
    Chin Med J (Engl). 2006 Jul 20;119(14):1198-203 PMID: 16863613
  47. Review article: complementary and alternative therapies for inflammatory bowel disease.
    Aliment Pharmacol Ther. 2006 Feb 1;23(3):341-9 PMID: 16422993
  48. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population.
    Aliment Pharmacol Ther. 2003 Jun 15;17(12):1465-70 PMID: 12823148
  49. [Activation of nuclear factor-kappaB and effects of anti-inflammatory treatment thereon in intestinal mucosa of patients with ulcerative colitis].
    Zhonghua Yi Xue Za Zhi. 2002 Mar 25;82(6):384-8 PMID: 11953203
Article Info
Journal
World journal of gastroenterology
Abbr.
World J Gastroenterol
ISSN
2219-2840
DOI
10.3748/wjg.15.788
Published
2009-02-21
Pages
788-803
Language
English
Region
United States
NLM ID
100883448
PMCID
PMC2653379
Subset
IM
External Links
PubMed source DOI: 10.3748/wjg.15.788 PMC Full Text View journal details
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