Metabolic enzymes as oncogenes or tumor suppressors.

The New England journal of medicine ·Vol. 360 ·No. 8 ·2009-02-19 ·Pages 813-5

Thompson CB

Abstract

暂无摘要

MeSH Terms

Brain Neoplasms/genetics DNA Mutational Analysis Fumarate Hydratase/genetics,metabolism Glioblastoma/genetics Glioma/genetics Humans Hypoxia-Inducible Factor 1/metabolism Isocitrate Dehydrogenase/genetics,metabolism Mutation Succinate Dehydrogenase/genetics,metabolism

Chemicals

Hypoxia-Inducible Factor 1 IDH2, human Isocitrate Dehydrogenase Succinate Dehydrogenase Fumarate Hydratase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Thompson Craig B

References (12)

12 references, click to expand

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.
Mol Cell Biol. 2007 May;27(9):3282-9 PMID: 17325041
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Cell Metab. 2008 Jan;7(1):11-20 PMID: 18177721
An integrated genomic analysis of human glioblastoma multiforme.
Science. 2008 Sep 26;321(5897):1807-12 PMID: 18772396
Analysis of the IDH1 codon 132 mutation in brain tumors.
Acta Neuropathol. 2008 Dec;116(6):597-602 PMID: 18985363
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle.
Nat Genet. 2008 Oct;40(10):1230-4 PMID: 18806796
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.
Oncogene. 2006 Aug 7;25(34):4675-82 PMID: 16892081
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity.
J Biol Chem. 2004 Aug 6;279(32):33946-57 PMID: 15173171
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases.
Gastroenterology. 2007 Nov;133(5):1637-48 PMID: 17983808
IDH1 and IDH2 mutations in gliomas.
N Engl J Med. 2009 Feb 19;360(8):765-73 PMID: 19228619
Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs.
Free Radic Biol Med. 2007 Oct 15;43(8):1197-207 PMID: 17854715
Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9001-6 PMID: 17517629
Regulation of replicative senescence by NADP+ -dependent isocitrate dehydrogenase.
Free Radic Biol Med. 2006 Jan 1;40(1):110-9 PMID: 16337884

Article Info

Journal

The New England journal of medicine

Abbr.

N Engl J Med

ISSN

1533-4406

DOI

10.1056/NEJMe0810213

Published

2009-02-19

Pages

813-5

Language

English

Region

United States

NLM ID

0255562

PMCID

PMC2848669

Subset

Grants

NCI NIH HHS · P01 CA104838-05 · United States

NCI NIH HHS · R01 CA105463-06 · United States

NCI NIH HHS · P01 CA104838 · United States

NCI NIH HHS · R01 CA105463 · United States

NCI NIH HHS · R01 CA092660 · United States

NCI NIH HHS · R01 CA092660-09 · United States

Corrections

CommentOn

PMID: 19228619

External Links

PubMed source DOI: 10.1056/NEJMe0810213 PMC Full Text View journal details

Analysis Services

Metabolic enzymes as oncogenes or tumor suppressors.

Contact

WeChat Official Account