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PMID: 19224140 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Unravelling the mechanisms of help for CD8+ T cell responses.

Immunologic research ·Vol. 45 ·No. 2-3 ·2009-12-00 ·Pages 209-17

Livingstone AM, Wilson EB, Ontiveros F, Wang JC

Abstract

CD8+ T cells are critically important for immune defense against many viral and bacterial pathogens, and are also key components of cancer immunotherapy. Help from CD4+ T cells is usually essential for optimal CD8+ T cell responses, driving the primary response, the survival of memory cells, and the generation of protective and therapeutic immunity. Understanding the mechanisms of help is thus essential for vaccine design, and for restoring protective immunity in immunosuppressed individuals. Our laboratory has developed an immunization protocol using peptide-pulsed dendritic cells to stimulate help-dependent primary, memory, and secondary CD8+ T cell responses. We have used gene-targeted and T cell receptor transgenic mice to identify two distinct pathways that generate help-dependent and help-independent CD8+ T cell responses, respectively, and are now starting to define the molecular mechanisms underlying these two pathways.

MeSH Terms
Animals CD4-Positive T-Lymphocytes/immunology,metabolism CD8-Positive T-Lymphocytes/immunology,metabolism Dendritic Cells/immunology Immunization/methods Immunologic Memory/immunology Mice Mice, Transgenic Models, Immunological Receptors, Antigen, T-Cell/genetics,immunology,metabolism Signal Transduction/immunology
Chemicals
Receptors, Antigen, T-Cell
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Livingstone Alexandra M
David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Rochester, NY, USA. alexandra_livingstone@urmc.rochester.edu
Wilson Elizabeth B
Ontiveros Fernando
Wang Jyh-Chiang E
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
1559-0755
DOI
10.1007/s12026-009-8102-0
Email
alexandra_livingstone@urmc.rochester.edu
Published
2009-12-00
Epub
2009-00-18
Pages
209-17
Language
English
Region
United States
NLM ID
8611087
Subset
IM
Grants
NIAID NIH HHS · AI007285 · United States
NIAID NIH HHS · AI48721 · United States
External Links
PubMed source DOI: 10.1007/s12026-009-8102-0 View journal details
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