Home LiteratureArticle Details
PMID: 1922004 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Molecular control of myogenesis: antagonism between growth and differentiation.

Molecular and cellular biochemistry ·Vol. 104 ·No. 1-2 ·1991-00-00 ·Pages 7-13

Olson EN, Brennan TJ, Chakraborty T, Cheng TC, Cserjesi P, Edmondson D, James G, Li L

Abstract

Insight into the molecular mechanisms that control establishment of the skeletal muscle phenotype has recently been obtained through cloning of a family of muscle-specific regulatory factors that can activate myogenesis when transfected into non-muscle cells. This family of factors, which includes MyoD, myogenin, myf-5, and MRF4, can bind DNA and transactivate muscle-specific genes in collaboration with ubiquitous cellular factors. Growth factors play an antagonistic role in myogenesis by suppressing the actions of the myogenic regulatory factor family. This review will focus on the regulation and mechanism of action of this family of myogenic regulatory factors and on the central role of peptide growth factors in modulating their expression and biological activities.

MeSH Terms
Animals Cell Differentiation Cell Division Genes, Regulator Growth Substances/physiology Humans Muscle Development Muscles/cytology,metabolism Oncogenes Transcription Factors/metabolism
Chemicals
Growth Substances Transcription Factors
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Olson E N
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Brennan T J
Chakraborty T
Cheng T C
Cserjesi P
Edmondson D
James G
Li L
References (35)
35 references, click to expand
  1. Regulation of myogenic differentiation by type beta transforming growth factor.
    J Cell Biol. 1986 Nov;103(5):1799-805 PMID: 3465734
  2. Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.
    EMBO J. 1990 Mar;9(3):821-31 PMID: 2311584
  3. Cell proliferation inhibited by MyoD1 independently of myogenic differentiation.
    Nature. 1990 Jun 28;345(6278):813-5 PMID: 2359457
  4. Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.
    J Cell Biol. 1987 Aug;105(2):949-56 PMID: 3624313
  5. Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes.
    J Cell Biol. 1988 Jun;106(6):2127-37 PMID: 3133379
  6. Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.
    Mol Cell Biol. 1989 Jun;9(6):2627-40 PMID: 2761542
  7. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.
    Cell. 1989 Aug 11;58(3):537-44 PMID: 2503252
  8. Effect of cell history on response to helix-loop-helix family of myogenic regulators.
    Nature. 1990 Mar 29;344(6265):454-8 PMID: 2157160
  9. A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.
    Genes Dev. 1989 May;3(5):628-40 PMID: 2473006
  10. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation.
    Cell. 1990 Mar 9;60(5):733-46 PMID: 2155707
  11. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer.
    Cell. 1989 Sep 8;58(5):823-31 PMID: 2550138
  12. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD.
    Proc Natl Acad Sci U S A. 1989 Jul;86(14):5434-8 PMID: 2748593
  13. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.
    Genes Dev. 1990 Feb;4(2):167-79 PMID: 2338243
  14. Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor alpha-subunit gene.
    Nature. 1990 May 24;345(6273):353-5 PMID: 2342565
  15. Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.
    J Biol Chem. 1986 Jul 15;261(20):9483-8 PMID: 3722206
  16. Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1.
    Cell. 1989 Aug 25;58(4):659-67 PMID: 2548731
  17. A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.
    EMBO J. 1989 Mar;8(3):701-9 PMID: 2721498
  18. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.
    Science. 1988 Oct 21;242(4877):405-11 PMID: 3175662
  19. Distinctive effects of the viral oncogenes myc, erb, fps, and src on the differentiation program of quail myogenic cells.
    Proc Natl Acad Sci U S A. 1985 Jan;82(2):426-30 PMID: 2982156
  20. Identification of MRF4: a new member of the muscle regulatory factor gene family.
    Genes Dev. 1989 Dec;3(12B):2050-61 PMID: 2560751
  21. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins.
    Cell. 1990 Apr 6;61(1):49-59 PMID: 2156629
  22. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
    Cell. 1989 Mar 10;56(5):777-83 PMID: 2493990
  23. Interaction with normal cells suppresses the transformed phenotype of v-myc-transformed quail muscle cells.
    Cell. 1989 Jul 14;58(1):123-31 PMID: 2752417
  24. M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription.
    Mol Cell Biol. 1990 Aug;10(8):4271-83 PMID: 2370866
  25. The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.
    Mol Cell Biol. 1987 Jun;7(6):2104-11 PMID: 3600660
  26. Herculin, a fourth member of the MyoD family of myogenic regulatory genes.
    Proc Natl Acad Sci U S A. 1990 Feb;87(3):1089-93 PMID: 2300571
  27. Transforming growth factor beta represses the actions of myogenin through a mechanism independent of DNA binding.
    Proc Natl Acad Sci U S A. 1991 May 1;88(9):3822-6 PMID: 1850837
  28. Expression of a single transfected cDNA converts fibroblasts to myoblasts.
    Cell. 1987 Dec 24;51(6):987-1000 PMID: 3690668
  29. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.
    Mol Cell Biol. 1989 Nov;9(11):5022-33 PMID: 2601707
  30. Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.
    EMBO J. 1989 Dec 1;8(12):3617-25 PMID: 2583111
  31. Positive autoregulation of the myogenic determination gene MyoD1.
    Cell. 1989 Jul 28;58(2):241-8 PMID: 2546677
  32. Autonomous expression of c-myc in BC3H1 cells partially inhibits but does not prevent myogenic differentiation.
    Mol Cell Biol. 1987 May;7(5):1973-7 PMID: 3299056
  33. Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.
    Genes Dev. 1990 Apr;4(4):582-95 PMID: 2163343
  34. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.
    Cell. 1989 Feb 24;56(4):607-17 PMID: 2537150
  35. Fibroblast growth factor and transforming growth factor beta repress transcription of the myogenic regulatory gene MyoD1.
    Mol Cell Biol. 1989 Aug;9(8):3576-9 PMID: 2797000
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00229797
Published
1991-00-00
Pages
7-13
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00229797 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2