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PMID: 19214220 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.

PLoS pathogens ·Vol. 5 ·No. 2 ·2009-02-00 ·Pages e1000295

Favre D, Lederer S, Kanwar B, Ma ZM, Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller CJ, Katze MG, McCune JM

Abstract

Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.

MeSH Terms
Analysis of Variance Animals CD8-Positive T-Lymphocytes/immunology,virology Chlorocebus aethiops Colon/immunology,metabolism Cytokines/immunology,metabolism Flow Cytometry Forkhead Transcription Factors/metabolism Interleukin-17/immunology,metabolism Lymph Nodes/immunology,metabolism Lymphocyte Activation Macaca nemestrina Male Oligonucleotide Array Sequence Analysis RNA, Viral/analysis,blood,metabolism Simian Acquired Immunodeficiency Syndrome/immunology,virology Simian Immunodeficiency Virus Statistics, Nonparametric T-Lymphocyte Subsets/immunology T-Lymphocytes, Helper-Inducer/immunology,virology T-Lymphocytes, Regulatory/immunology,virology Viral Load
Chemicals
Cytokines Forkhead Transcription Factors Interleukin-17 RNA, Viral
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Favre David
Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America.
Lederer Sharon
Kanwar Bittoo
Ma Zhong-Min
Proll Sean
Kasakow Zeljka
Mold Jeff
Swainson Louise
Barbour Jason D
Baskin Carole R
Palermo Robert
Pandrea Ivona
Miller Christopher J
Katze Michael G
McCune Joseph M
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Article Info
Journal
PLoS pathogens
Abbr.
PLoS Pathog
ISSN
1553-7374
DOI
10.1371/journal.ppat.1000295
Published
2009-02-00
Epub
2009-00-13
Pages
e1000295
Language
English
Region
United States
NLM ID
101238921
PMCID
PMC2635016
Subset
IM
Grants
NIAID NIH HHS · R01 AI44480 · United States
NCRR NIH HHS · P51RR000166 · United States
NIAID NIH HHS · K01 AI066917 · United States
NIAID NIH HHS · AI076014 · United States
NIDDK NIH HHS · T32 DK007762 · United States
NCRR NIH HHS · R24 RR016354 · United States
NIAID NIH HHS · AI066917 · United States
NCRR NIH HHS · P51 RR000169 · United States
NCRR NIH HHS · U51RR00169 · United States
NIDDK NIH HHS · K24 DK060617 · United States
NCRR NIH HHS · R24RR016354 · United States
NIH HHS · DPI OD00329 · United States
NIAID NIH HHS · N01AI30018 · United States
NIAID NIH HHS · P01 AI066314 · United States
NCRR NIH HHS · P51 RR000166 · United States
NIDA NIH HHS · P30 DA015625 · United States
NIH HHS · DP1 OD000329 · United States
NIDA NIH HHS · P30DA015625 · United States
NIAID NIH HHS · R21 AI076014 · United States
External Links
PubMed source DOI: 10.1371/journal.ppat.1000295 PMC Full Text View journal details
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