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题目:: Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status.
作者:: Ha(Seon-Ah),Lee(Youn Soo),Shin(Seung Min),Kim(Hyun Kee),Kim(Sanghee),Namkoong(Hong),Kim(Hae Joo),Jung(Sang Min),Lee(Yu Sun),Chung(Yeun Jun),Jung(Sang Seol),Kim(Jin Woo)
状态:: 发布时间2009-04-24 , 更新时间 2014-12-10
期刊:: BMC Cancer
摘要:: Oncoprotein HCCR-1 functions as a negative regulator of the p53 and contributes breast tumorigenesis. The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast cancers. But it is unknown how HCCR-1 contributes to human breast tumorigenesis.,Oncogene HCCR-1 expression levels were determined in normal breast tissues, breast cancer tissues and cancer cell lines. We examined whether HCCR-1 protein expression in breast cancer is related to different biological characteristics, including ER, PR, p53 genotype, and HER2 status in 104 primary breast cancer tissues using immunohistochemical analyses.,HCCR-1 was upregulated in breast cancer cells and tissues compared with normal breast tissues. In this study, overexpression of HCCR-1 was well correlated with known breast cancer prognostic markers including the presence of steroid receptors (ER and PR), p53 mutation and high HER2 overexpression. HCCR-1 was not detected in the ER-negative, PR-negative, p53 negative and low HER2 breast cancer tissues. These data indicate that the level of HCCR-1 in breast cancer tissues is relatively well correlated with known breast cancer factors, including the HER2 overexpression, p53 mutation, and ER/PR status.,Determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation.
语言:: eng
DOI:

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