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PMID: 19200890 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Methods to monitor chaperone-mediated autophagy.

Methods in enzymology ·Vol. 452 ·2009-00-00 ·Pages 297-324

Kaushik S, Cuervo AM

Abstract

Chaperone-mediated autophagy (CMA) is a selective type of autophagy responsible for the lysosomal degradation of soluble cytosolic proteins. In contrast to other forms of autophagy where cargo is sequestered and delivered to lysosomes through membrane fusion/excision, CMA substrates reach the lysosomal lumen after direct translocation across the lysosomal membrane. CMA is part of the cellular quality control systems and as such, essential for the cellular response to stress. CMA activity decreases with age, likely contributing to the accumulation of altered proteins characteristic in tissues from old organisms. Furthermore, impairment of CMA underlies the pathogenesis of certain human pathologies such as neurodegenerative disorders. These findings have drawn renewed attention to CMA and a growing interest in the measurement of changes in CMA activity under different physiological and pathological conditions. In this chapter we review the different experimental approaches used to assess CMA activity both in cells in culture and in different organs from animals.

MeSH Terms
Animals Autophagy/physiology HSC70 Heat-Shock Proteins/metabolism Immunoblotting Lysosomal-Associated Membrane Protein 2/metabolism Lysosomes/metabolism Mice Mice, Transgenic
Chemicals
HSC70 Heat-Shock Proteins Lysosomal-Associated Membrane Protein 2
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kaushik Susmita
Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, USA.
Cuervo Ana Maria
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Article Info
Journal
Methods in enzymology
Abbr.
Methods Enzymol
ISSN
1557-7988
Published
2009-00-00
Pages
297-324
Language
English
Region
United States
NLM ID
0212271
PMCID
PMC4300957
Subset
IM
Grants
NIDDK NIH HHS · P30 DK041296 · United States
NIDDK NIH HHS · P01 DK041918 · United States
NIA NIH HHS · AG031782 · United States
NIA NIH HHS · R37 AG021904 · United States
NIDDK NIH HHS · R01 DK098408 · United States
NIA NIH HHS · R01 AG021904 · United States
NIDDK NIH HHS · DK041918 · United States
NIA NIH HHS · P01 AG031782 · United States
NIA NIH HHS · AG021904 · United States
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