Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets.

Prostaglandins ·Vol. 13 ·No. 3 ·1977-03-00 ·Pages 389-97

Tateson JE, Moncada S, Vane JR

Abstract

Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets. Prostacyclin is approximately 10 times more active than PGD2, 30 times more active than PGE1 and more than 1000 times more active than its stable end product, 6-oxo-PGF1alpha. These results correlate well with the anti-aggregating activity of prostacyclin, compared with PGE1 and PGD2.

MeSH Terms

Arachidonic Acids/pharmacology Blood Platelets/metabolism Cyclic AMP/blood Dose-Response Relationship, Drug Humans Platelet Aggregation/drug effects Prostaglandins E/pharmacology Prostaglandins F/pharmacology

Chemicals

Arachidonic Acids Prostaglandins E Prostaglandins F Cyclic AMP

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Tateson J E

Moncada S

Vane J R

Article Info

Journal

Prostaglandins

Abbr.

Prostaglandins

ISSN

0090-6980

DOI

10.1016/0090-6980(77)90019-3

Published

1977-03-00

Pages

389-97

Language

English

Region

United States

NLM ID

0320271

Subset

External Links

PubMed source DOI: 10.1016/0090-6980(77)90019-3

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Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets.

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