Granulocyte collagenase: selective digestion of type I relative to type III collagen.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 3 ·1977-03-00 ·Pages 897-901

Horwitz AL, Hance AJ, Crystal RG

Abstract

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.

MeSH Terms

Animals Fibroblasts/enzymology Humans Macrophages/enzymology Microbial Collagenase/antagonists & inhibitors,metabolism Neutrophils/enzymology Rabbits

Chemicals

Microbial Collagenase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Horwitz A L

Hance A J

Crystal R G

References (28)

28 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.74.3.897

Published

1977-03-00

Pages

897-901

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC430521

Subset

External Links

PubMed source DOI: 10.1073/pnas.74.3.897 PMC Full Text View journal details

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Granulocyte collagenase: selective digestion of type I relative to type III collagen.

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