Abstract
Models of the differentiation of memory CD8+ T cells that replicate during secondary infections differ over whether such cells had acquired effector function during primary infections. We created a transgenic mouse line that permits mapping of the fate of granzyme B (gzmB)-expressing CD8+ T cells and their progeny by indelibly marking them with enhanced yellow fluorescent protein (EYFP). Virus-specific CD8+ T cells express gzmB within the first 2 days of a primary response to infection with influenza, without impairment of continued primary clonal expansion. On secondary infection, virus-specific CD8+ T cells that became EYFP+ during a primary infection clonally expand as well as all virus-specific CD8+ T cells. Thus, CD8+ T cells that have acquired an effector phenotype during primary infection may function as memory cells with replicative function.
MeSH Terms
Animals
CD8-Positive T-Lymphocytes/cytology,immunology
Cell Differentiation
Cell Division
Granzymes/genetics,metabolism
Immunologic Memory
Influenza A Virus, H1N1 Subtype/immunology
Influenza A Virus, H3N2 Subtype/immunology
Luminescent Proteins/genetics,metabolism
Lung/immunology
Mice
Mice, Transgenic
Orthomyxoviridae Infections/immunology
Phenotype
Spleen/immunology
T-Lymphocyte Subsets/cytology,immunology
Chemicals
Luminescent Proteins
Granzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bannard Oliver
Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK.
Kraman Matthew
Fearon Douglas T
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