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PMID: 19157572 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Elevated immune response in the brain of autistic patients.

Journal of neuroimmunology ·Vol. 207 ·No. 1-2 ·2009-02-15 ·Pages 111-6

Li X, Chauhan A, Sheikh AM, Patil S, Chauhan V, Li XM, Ji L, Brown T, Malik M

Abstract

This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue. Our results showed that proinflammatory cytokines (TNF-alpha, IL-6 and GM-CSF), Th1 cytokine (IFN-gamma) and chemokine (IL-8) were significantly increased in the brains of ASD patients compared with the controls. However the Th2 cytokines (IL-4, IL-5 and IL-10) showed no significant difference. The Th1/Th2 ratio was also significantly increased in ASD patients. ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD.

MeSH Terms
Adolescent Adult Autistic Disorder/immunology,pathology Brain/immunology,pathology Case-Control Studies Chemokines/metabolism Child Child, Preschool Cytokines/metabolism Female Humans Male Statistics, Nonparametric Th1 Cells/immunology Th2 Cells/immunology Young Adult
Chemicals
Chemokines Cytokines
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Li Xiaohong
Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA. xiaohong.li@mssm.edu
Chauhan Abha
Sheikh Ashfaq M
Patil Sangita
Chauhan Ved
Li Xiu-Min
Ji Lina
Brown Ted
Malik Mazhar
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Article Info
Journal
Journal of neuroimmunology
Abbr.
J Neuroimmunol
ISSN
0165-5728
DOI
10.1016/j.jneuroim.2008.12.002
Email
xiaohong.li@mssm.edu
Published
2009-02-15
Epub
2009-00-20
Pages
111-6
Language
English
Region
Netherlands
NLM ID
8109498
PMCID
PMC2770268
Subset
IM
Grants
NCCIH NIH HHS · P01 AT002647 · United States
NCCIH NIH HHS · P01 AT002647-040001 · United States
NCCIH NIH HHS · P01 AT002647-040002 · United States
External Links
PubMed source DOI: 10.1016/j.jneuroim.2008.12.002 PMC Full Text View journal details
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