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PMID: 19154715 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease.

Developmental cell ·Vol. 16 ·No. 1 ·2009-01-00 ·Pages 12-20

Skwarek LC, Boulianne GL

Abstract

Phosphoinositides function as signaling precursors as well as regulators and scaffolds of signaling molecules required for important cellular processes such as membrane trafficking. Although a picture of the biochemical and cell biological functions of phosphoinositides is emerging, less is known about how these functions impact signaling on a broader scale during development. This review summarizes recent work on the role of phosphoinositides in developmental signaling and in a number of diseases and developmental disorders.

MeSH Terms

Animals Blastoderm/physiology Body Patterning/physiology Cell Division Cell Polarity Endocytosis/physiology Gastrulation/physiology Humans Molecular Structure Morphogenesis/physiology Phosphatidylinositol 3-Kinases/metabolism Phosphatidylinositols/chemistry,metabolism Phosphoinositide-3 Kinase Inhibitors Plant Development Plant Growth Regulators/metabolism Plants/metabolism Receptor Protein-Tyrosine Kinases/metabolism Receptors, Notch/metabolism Signal Transduction/physiology

Chemicals

Phosphatidylinositols Phosphoinositide-3 Kinase Inhibitors Plant Growth Regulators Receptors, Notch Receptor Protein-Tyrosine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Skwarek Lara C

The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, ON, Canada.

Boulianne Gabrielle L

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1878-1551

DOI

10.1016/j.devcel.2008.12.006

Published

2009-01-00

Pages

12-20

Language

English

Region

United States

NLM ID

101120028

Subset

External Links

PubMed source DOI: 10.1016/j.devcel.2008.12.006 View journal details

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Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease.

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