Temperature regulation of the cryptococcal phenoloxidase.

Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology ·Vol. 29 ·No. 2 ·1991-00-00 ·Pages 121-4

Jacobson ES, Emery HS

Abstract

Melanin formation at 37 degrees C has been proposed as a virulence factor in Cryptococcus neoformans. However, whereas catecholamine uptake is maintained at this temperature, phenoloxidase, which catalyses the oxidation of catecholamine to melanin, is severely decreased in most wild type strains cultivated at 37 degrees C.

MeSH Terms

Catecholamines/metabolism Cryptococcus neoformans/enzymology,pathogenicity Melanins/biosynthesis Monophenol Monooxygenase/metabolism Oxidation-Reduction Temperature Urease/metabolism Virulence

Chemicals

Catecholamines Melanins Monophenol Monooxygenase Urease

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jacobson E S

Research Service, McGuire Veterans Affairs Medical Centre, Richmond, Virginia 23249.

Emery H S

Article Info

Journal

Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology

Abbr.

J Med Vet Mycol

ISSN

0268-1218

DOI

10.1080/02681219180000201

Published

1991-00-00

Pages

121-4

Language

English

Region

England

NLM ID

8605493

Subset

External Links

PubMed source DOI: 10.1080/02681219180000201

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Temperature regulation of the cryptococcal phenoloxidase.

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