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PMID: 19088733 Published · ppublish English Journal Article Comment

Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes.

Nature immunology ·Vol. 10 ·No. 1 ·2009-01-00 ·Pages 11-2

Malmberg KJ, Ljunggren HG

Abstract

New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.

MeSH Terms
Animals Homeostasis/physiology Humans Interleukins/biosynthesis Intestinal Mucosa/immunology,microbiology Killer Cells, Natural/immunology,metabolism Lymphoid Tissue/immunology Mice Natural Cytotoxicity Triggering Receptor 1/metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 Receptors, Natural Killer Cell/metabolism Receptors, Retinoic Acid/immunology Receptors, Thyroid Hormone/immunology T-Lymphocyte Subsets/immunology,metabolism
Chemicals
Interleukins NCR1 protein, human Natural Cytotoxicity Triggering Receptor 1 Nuclear Receptor Subfamily 1, Group F, Member 3 RORC protein, human Receptors, Natural Killer Cell Receptors, Retinoic Acid Receptors, Thyroid Hormone Rorc protein, mouse interleukin-22
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Malmberg Karl-Johan
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
Ljunggren Hans-Gustaf
References (10)
10 references, click to expand
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  8. Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells.
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  9. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells.
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni0109-11
Published
2009-01-00
Pages
11-2
Language
English
Region
United States
NLM ID
100941354
Subset
IM
Corrections
CommentOn
PMID: 19029903
CommentOn
PMID: 19029904
CommentOn
PMID: 19029905
External Links
PubMed source DOI: 10.1038/ni0109-11 View journal details
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