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PMID: 1908022 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Strand-specific nucleotide composition bias in echinoderm and vertebrate mitochondrial genomes.

Journal of molecular evolution ·Vol. 32 ·No. 6 ·1991-06-00 ·Pages 511-20

Asakawa S, Kumazawa Y, Araki T, Himeno H, Miura K, Watanabe K

Abstract

The gene organization of starfish mitochondrial DNA is identical with that of the sea urchin counterpart except for a reported inversion of an approximately 4.6-kb segment containing two structural genes for NADH dehydrogenase subunits 1 and 2 (ND 1 and ND 2). When the codon usage of each structural gene in starfish, sea urchin, and vertebrate mitochondrial DNAs is examined, it is striking that codons ending in T and G are preferentially used more for heavy strand-encoded genes, including starfish ND 1 and ND 2, than for light strand-encoded genes, including sea urchin ND 1 and ND 2. On the contrary, codons ending in A and C are preferentially used for the light strand-encoded genes rather than for the heavy strand-encoded ones. Moreover, G-U base pairs are more frequently found in the possible secondary structures of heavy strand-encoded tRNAs than in those of light strand-encoded tRNAs. These observations suggest the existence of a certain constraint operating on mitochondrial genomes from various animal phyla, which results in the accumulation of G and T on one strand, and A and C on the other.

MeSH Terms
Amino Acid Sequence Animals Anura Base Composition Base Sequence Chickens Codon DNA Replication DNA, Mitochondrial/chemistry Drosophila Genes Humans Mice Molecular Sequence Data RNA, Transfer/chemistry Starfish/genetics
Chemicals
Codon DNA, Mitochondrial RNA, Transfer
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Asakawa S
Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Japan.
Kumazawa Y
Araki T
Himeno H
Miura K
Watanabe K
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02102653
Published
1991-06-00
Pages
511-20
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02102653 View journal details
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