| GeneLibs

题目:: Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
作者:: Baehs(Sebastian),Herbst(Andreas),Thieme(Susanne E),Perschl(Claudia),Behrens(Andrea),Scheel(Silvio),Jung(Andreas),Brabletz(Thomas),Göke(Burkhard),Blum(Helmut),Kolligs(Frank T)
状态:: 发布时间2009-03-03 , 更新时间 2010-11-18
期刊:: Cancer Lett
摘要:: Like Dickkopf-1 (DKK1), DKK4 is a target of beta-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated beta-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal beta-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth.
语言:: eng
DOI:: 10.1016/j.canlet.2008.11.003

文献库文献相关信息