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PMID: 19056977 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Patterning mechanisms of branched organs.

Science (New York, N.Y.) ·Vol. 322 ·No. 5907 ·2008-12-05 ·Pages 1506-9

Lu P, Werb Z

Abstract

Branching morphogenesis is one of the earliest events essential for the success of metazoans. By branching out and forming cellular or tissue extensions, cells can maximize their surface area and overcome space constraints posed by organ size. Over the past decade, tremendous progress has been made toward understanding the branching mechanisms of various invertebrate and vertebrate organ systems. Despite their distinct origins, morphologies and functions, different cell and tissue types use a remarkably conserved set of tools to undergo branching morphogenesis. Recent studies have shed important light on the basis of molecular conservation in the formation of branched structures in diverse organs.

MeSH Terms
Animals Blood Vessels/embryology,physiology Body Patterning Cell Differentiation Epithelium/embryology,physiology Genes Mesoderm/embryology,physiology Morphogenesis Nervous System/embryology Neurons/cytology Organogenesis Regeneration Signal Transduction Stem Cells/physiology Stromal Cells/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lu Pengfei
Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143-0452, USA.
Werb Zena
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1162783
Published
2008-12-05
Pages
1506-9
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2645229
Subset
IM
Grants
NIEHS NIH HHS · U01 ES012801-06 · United States
NCI NIH HHS · CA057621 · United States
NIEHS NIH HHS · ES012801 · United States
NIEHS NIH HHS · U01 ES012801 · United States
NCI NIH HHS · R01 CA057621-16A1 · United States
NCI NIH HHS · R01 CA057621 · United States
External Links
PubMed source DOI: 10.1126/science.1162783 PMC Full Text View journal details
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