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PMID: 19041774 Published · ppublish English Letter Research Support, Non-U.S. Gov't

Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts.

Cell stem cell ·Vol. 3 ·No. 6 ·2008-12-04 ·Pages 587-90

Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H

Abstract

Induced pluripotent stem (iPS) cells can be generated from somatic cells by transduction with several transcription factors in mouse and human. However, direct reprogramming in other species has not been reported. Here, we generated monkey iPS cells by retrovirus-mediated introduction of monkey transcription factors OCT4, SOX2, KLF4, and c-MYC.

MeSH Terms
Animals Biomarkers/analysis,metabolism Cell Culture Techniques/methods Cell Differentiation/drug effects,genetics Cell Proliferation/drug effects Cell Shape/drug effects,genetics Cells, Cultured Culture Media/chemistry,pharmacology Embryonic Development/genetics Fibroblasts/cytology,drug effects,metabolism Gene Expression Regulation/genetics Genetic Vectors/genetics Germ Layers/cytology,metabolism Kruppel-Like Factor 4 Kruppel-Like Transcription Factors/genetics Macaca mulatta/anatomy & histology,physiology Male Octamer Transcription Factor-3/genetics Pluripotent Stem Cells/cytology,metabolism Proto-Oncogene Proteins c-myc/genetics Retroviridae/genetics SOXB1 Transcription Factors/genetics Transcription Factors/genetics Transduction, Genetic/methods
Chemicals
Biomarkers Culture Media KLF4 protein, human Klf4 protein, mouse Kruppel-Like Factor 4 Kruppel-Like Transcription Factors Octamer Transcription Factor-3 POU5F1 protein, human Proto-Oncogene Proteins c-myc SOX2 protein, human SOXB1 Transcription Factors Transcription Factors
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Liu Haisong
Zhu Fangfang
Yong Jun
Zhang Pengbo
Hou Pingping
Li Honggang
Jiang Wei
Cai Jun
Liu Meng
Cui Kai
Qu Xiuxia
Xiang Tingting
Lu Danyu
Chi Xiaochun
Gao Ge
Ji Weizhi
Ding Mingxiao
Deng Hongkui
Article Info
Journal
Cell stem cell
Abbr.
Cell Stem Cell
ISSN
1875-9777
DOI
10.1016/j.stem.2008.10.014
Published
2008-12-04
Pages
587-90
Language
English
Region
United States
NLM ID
101311472
Subset
IM
External Links
PubMed source DOI: 10.1016/j.stem.2008.10.014 View journal details
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