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PMID: 19039320 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Newly discovered roles for basophils: a neglected minority gains new respect.

Nature reviews. Immunology ·Vol. 9 ·No. 1 ·2009-01-00 ·Pages 9-13

Karasuyama H, Mukai K, Tsujimura Y, Obata K

Abstract

Basophils are the least common type of granulocyte and they account for less than 1% of peripheral blood leukocytes. Because of this minority status and a phenotype that is similar to mast cells, basophils have often been neglected in immunological studies or considered to have minor, redundant roles in immune responses in vivo. However, recent studies have now defined previously unrecognized roles for basophils in both immune regulation and allergic responses, and have shown that basophils and mast cells have distinct roles in immune responses.

MeSH Terms
Anaphylaxis/immunology Animals Basophils/immunology,metabolism Dermatitis, Atopic/immunology Histamine Release Humans Hypersensitivity/immunology Immunoglobulin E/immunology Immunoglobulin G/immunology Immunologic Memory Leukotriene C4/metabolism Mast Cells/physiology Mice Th2 Cells/cytology,immunology
Chemicals
Immunoglobulin G Leukotriene C4 Immunoglobulin E
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Karasuyama Hajime
Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. karasuyama.mbch@tmd.ac.jp
Mukai Kaori
Tsujimura Yusuke
Obata Kazushige
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2458
Email
karasuyama.mbch@tmd.ac.jp
Published
2009-01-00
Pages
9-13
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri2458 View journal details
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