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PMID: 19014406 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Local control by radiotherapy: is that all there is?

Breast cancer research : BCR ·Vol. 10 ·No. 6 ·2008-00-00 ·Pages 215

Formenti SC, Demaria S

Abstract

Radiotherapy is a local treatment modality employed in breast cancer to reduce local recurrence following surgery. The observed association of optimal local control with improved survival was not expected in a disease characterized by early systemic spread. The underlying mechanisms whereby the application of ionizing radiation to the primary tumor site can have systemic effects remain unclear and are the subject of much debate. In the present article we discuss the hypothesis that radiotherapy has unique biological effects and that, in addition to killing residual neoplastic cells after surgery is performed, it might favorably alter the microenvironment at the primary tumor site during the process of wound healing and the development of antitumor immune responses.

MeSH Terms
Breast Neoplasms/pathology,radiotherapy,surgery Female Humans Neoplasm Recurrence, Local/prevention & control
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Formenti Silvia C
Department of Radiation Oncology, New York University School of Medicine and NYU Cancer Institute, 160 East 34th Street, New York, NY 10016, USA. silvia.formenti@med.nyu.edu
Demaria Sandra
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Article Info
Journal
Breast cancer research : BCR
Abbr.
Breast Cancer Res
ISSN
1465-542X
DOI
10.1186/bcr2160
Email
silvia.formenti@med.nyu.edu
Published
2008-00-00
Epub
2008-00-05
Pages
215
Language
English
Region
England
NLM ID
100927353
PMCID
PMC2656907
Subset
IM
Grants
NCI NIH HHS · P30 CA016087 · United States
NCI NIH HHS · R01 CA113851 · United States
NCI NIH HHS · R01 CA113851-02 · United States
NCI NIH HHS · 5P30CA016087-27 · United States
External Links
PubMed source DOI: 10.1186/bcr2160 PMC Full Text View journal details
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