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PMID: 19005045 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 28 ·No. 46 ·2008-11-12 ·Pages 11814-8

Kilduff TS, Lein ES, de la Iglesia H, Sakurai T, Fu YH, Shaw P

Abstract

Understanding the mechanisms that underlie the control of sleep and wakefulness is a major research area in neuroscience. This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field. The studies discussed below use organisms ranging from flies to humans and focus on the interaction between the sleep homeostatic and circadian systems, the consequences of mutations in genes involved in the circadian clock on sleep timing, the effects of sleep deprivation on brain gene expression, the discovery of "sleep active" neurons in the cerebral cortex, the role of the hypocretin/orexin system in the maintenance of sleep and wakefulness, and the interaction between sleep and learning.

MeSH Terms
Animals Brain/physiology Circadian Rhythm/genetics Gene Expression Regulation/genetics Humans Intracellular Signaling Peptides and Proteins/physiology Molecular Biology/methods,trends Mutation/genetics Nerve Net/physiology Neuropeptides/physiology Neurosciences/methods,trends Orexins Sleep/genetics Systems Biology/methods,trends
Chemicals
Intracellular Signaling Peptides and Proteins Neuropeptides Orexins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kilduff Thomas S
Biosciences Division, SRI International, Menlo Park, California 94025, USA. thomas.kilduff@sri.com
Lein Ed S
de la Iglesia Horacio
Sakurai Takeshi
Fu Ying-Hui
Shaw Paul
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.3768-08.2008
Email
thomas.kilduff@sri.com
Published
2008-11-12
Pages
11814-8
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC2628168
Subset
IM
Grants
NHLBI NIH HHS · R01HL059658 · United States
NINDS NIH HHS · NS051305 · United States
NIMH NIH HHS · R01MH075016 · United States
NHLBI NIH HHS · R01 HL059658 · United States
NIA NIH HHS · R01AG020584 · United States
NIMH NIH HHS · R01 MH061755 · United States
NHLBI NIH HHS · R01 HL059596 · United States
NIMH NIH HHS · R01MH061755 · United States
NIMH NIH HHS · P50MH074924 · United States
NIMH NIH HHS · R01 MH061755-09 · United States
NIMH NIH HHS · R01 MH075016 · United States
NHLBI NIH HHS · R01HL059596 · United States
NIMH NIH HHS · P50 MH074924 · United States
NIA NIH HHS · R01 AG020584 · United States
NINDS NIH HHS · R01 NS051305 · United States
NHLBI NIH HHS · R01 HL059658-09 · United States
NIA NIH HHS · R01 AG020584-05 · United States
External Links
PubMed source DOI: 10.1523/JNEUROSCI.3768-08.2008 PMC Full Text View journal details
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