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PMID: 1899288 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene.

Molecular and cellular biology ·Vol. 11 ·No. 2 ·1991-02-00 ·Pages 906-12

Viskochil D, Cawthon R, O'Connell P, Xu GF, Stevens J, Culver M, Carey J, White R

Abstract

In the course of efforts to identify the neurofibromatosis type 1 gene (NF1), three genes were found embedded within an intron of NF1. The cDNA sequence of one of these genes (OMGP) encodes oligodendrocyte-myelin glycoprotein. OMGP spans at least 2.7 kb of genomic DNA, and it maps within 4 kb of the breakpoint of a balanced chromosomal translocation carried by an individual with NF1. OMGP is similar in genomic structure to two other expressed genes, EVI2A and EVI2B, which lie approximately 20 and 5 kb telomeric of the OMGP locus, respectively. All three genes have the same transcriptional orientation and are contained within one intron of NF1, which is transcribed off the opposite strand. Whether altered expression of OMGP might play a role in the clinical heterogeneity of NF1 is as yet unclear.

Related Genes
EV12A EV12B OMGP
MeSH Terms
Amino Acid Sequence Base Sequence Biological Evolution Cell Line Child, Preschool Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 17 Cloning, Molecular Female GPI-Linked Proteins Gene Library Humans Introns Membrane Glycoproteins/genetics Molecular Sequence Data Myelin Proteins Myelin-Associated Glycoprotein Myelin-Oligodendrocyte Glycoprotein Nerve Tissue Proteins/genetics Neurofibromatosis 1/genetics Restriction Mapping Translocation, Genetic
Chemicals
GPI-Linked Proteins MOG protein, human Membrane Glycoproteins Myelin Proteins Myelin-Associated Glycoprotein Myelin-Oligodendrocyte Glycoprotein Nerve Tissue Proteins OMG protein, human
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Viskochil D
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
Cawthon R
O'Connell P
Xu G F
Stevens J
Culver M
Carey J
White R
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.11.2.906-912.1991
Published
1991-02-00
Pages
906-12
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC359746
Subset
IM
Databases
GENBANK
M63623, M64561, M64562, M64563, M64564, M64565, M64566, X54237, X54238, X54323
External Links
PubMed source DOI: 10.1128/mcb.11.2.906-912.1991 PMC Full Text View journal details
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