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PMID: 1899186 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sequence of the beta-subunit of the phosphatidylinositol-specific phospholipase C-directed GTP-binding protein from squid (Loligo forbesi) photoreceptors.

The Biochemical journal ·Vol. 273(Pt 1) ·1991-01-01 ·Pages 225-8

Ryba NJ, Pottinger JD, Keen JN, Findlay JB

Abstract

The beta-subunit (G-beta) of the squid (Loligo forbesi) visual GTP-binding protein (G-protein), thought to be associated with a phosphatidylinositol-specific phospholipase C, has been identified and the sequence of the protein determined from its cDNA. The predicted polypeptide has a very marked sequence similarity with its mammalian counterparts (80-90% identity). Squid G-beta also has somewhat lower similarity to the yeast protein STE4 (approx. 40% identity). The role of G-beta in signal transduction is discussed in the light of its pronounced structural conservation.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cattle DNA/genetics Decapodiformes Drosophila/genetics Electrophoresis, Polyacrylamide Gel GTP-Binding Proteins/genetics Humans Molecular Sequence Data Phosphatidylinositols/metabolism Photoreceptor Cells/metabolism Saccharomyces cerevisiae/genetics Sequence Homology, Nucleic Acid Type C Phospholipases/metabolism
Chemicals
Phosphatidylinositols DNA Type C Phospholipases GTP-Binding Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ryba N J
Department of Biochemistry, University of Leeds, U.K.
Pottinger J D
Keen J N
Findlay J B
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2730225
Published
1991-01-01
Pages
225-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1149903
Subset
IM
Databases
GENBANK
M64055, M64056, M64057, M64058, M64059, M64060, M83107, S67100, S78039, X56757
External Links
PubMed source DOI: 10.1042/bj2730225 PMC Full Text View journal details
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