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PMID: 18984155 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The self-tuning neuron: synaptic scaling of excitatory synapses.

Cell ·Vol. 135 ·No. 3 ·2008-10-31 ·Pages 422-35

Turrigiano GG

Abstract

Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.

MeSH Terms
Animals Brain/physiology Homeostasis Humans Neuronal Plasticity Neurons/physiology Synapses/physiology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Turrigiano Gina G
Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. turrigiano@brandeis.edu
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2008.10.008
Email
turrigiano@brandeis.edu
Published
2008-10-31
Pages
422-35
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2834419
Subset
IM
Grants
NINDS NIH HHS · R01 NS036853 · United States
NINDS NIH HHS · NS 36853 · United States
NINDS NIH HHS · R56 NS036853 · United States
NINDS NIH HHS · R01 NS036853-03 · United States
NEI NIH HHS · R01 EY014439 · United States
NEI NIH HHS · EY14439 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2008.10.008 PMC Full Text View journal details
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