Tolerance and reactivity of NK cells: two sides of the same coin?
作者:
Held(Werner)
状态:
发布时间2008-11-12
, 更新时间 2008-11-12
期刊:
Eur J Immunol
摘要:
NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are prevented from attacking normal cells while ensuring reactivity to diseased cells is a major unresolved question for NK-cell biologists.