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PMID: 18953558 Published · ppublish English Journal Article Review

Tumor-host interactions: the role of inflammation.

Histochemistry and cell biology ·Vol. 130 ·No. 6 ·2008-12-00 ·Pages 1079-90

Le Bitoux MA, Stamenkovic I

Abstract

It is well established that interactions between tumor cells and the host tissue stroma play a key role in determining whether and how any given solid malignancy will develop. In most cases, tumor cells hijack stromal cell functions for their own benefit and ultimately dictate the rules of engagement to the host tissue microenvironment. However, the contribution of the different stromal cell components to tumor growth remains to be clarified. Because most solid tumors are accompanied by a local inflammatory response, it has long been thought that inflammation and carcinogenesis are related. If formal proof that cancer can be initiated by inflammation in the absence of exogenous carcinogens is still lacking, there is abundant evidence that the inflammatory response can play a central role in modulating tumor growth and progression. This review will discuss some of the mechanisms whereby inflammation can both enhance and inhibit tumor growth.

MeSH Terms
Animals Chemotaxis, Leukocyte Humans Inflammation/immunology,metabolism,pathology Inflammation Mediators/metabolism Leukocytes/immunology,metabolism Lymphocytes, Tumor-Infiltrating/immunology,metabolism Macrophages/immunology,metabolism Neoplasm Metastasis Neoplasms/immunology,metabolism,pathology,prevention & control Stromal Cells/immunology,metabolism,pathology Tumor Escape
Chemicals
Inflammation Mediators
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Le Bitoux Marie-Aude
Division of Experimental Pathology, Institute of Pathology, CHUV, Lausanne, Switzerland.
Stamenkovic Ivan
References (83)
83 references, click to expand
  1. Tumour immunity: effector response to tumour and role of the microenvironment.
    Lancet. 2008 Mar 1;371(9614):771-83 PMID: 18275997
  2. The inflammasome, autoinflammatory diseases, and gout.
    Joint Bone Spine. 2007 Dec;74(6):571-6 PMID: 17714972
  3. IL-1, IL-18, and IL-33 families of cytokines.
    Immunol Rev. 2008 Jun;223:20-38 PMID: 18613828
  4. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
    Cancer Res. 1999 Oct 1;59(19):5002-11 PMID: 10519415
  5. Wnt/beta-catenin signaling in cancer stemness and malignant behavior.
    Curr Opin Cell Biol. 2007 Apr;19(2):150-8 PMID: 17306971
  6. NLRs at the intersection of cell death and immunity.
    Nat Rev Immunol. 2008 May;8(5):372-9 PMID: 18362948
  7. Prognostic influence of tumor-infiltrating mast cells in patients with follicular lymphoma treated with rituximab and CHOP.
    Blood. 2008 May 1;111(9):4664-7 PMID: 18309035
  8. Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force.
    Ann Intern Med. 2007 Mar 6;146(5):376-89 PMID: 17339623
  9. Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.
    Cancer. 2008 Sep 15;113(6):1387-95 PMID: 18671239
  10. TNF-alpha in promotion and progression of cancer.
    Cancer Metastasis Rev. 2006 Sep;25(3):409-16 PMID: 16951987
  11. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.
    Nat Rev Cancer. 2001 Oct;1(1):11-21 PMID: 11900248
  12. NF-kappaB and cancer-identifying targets and mechanisms.
    Curr Opin Genet Dev. 2008 Feb;18(1):19-26 PMID: 18440219
  13. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line.
    J Exp Med. 1989 Apr 1;169(4):1485-90 PMID: 2926331
  14. Inflammation, proteases and cancer.
    Eur J Cancer. 2006 Apr;42(6):728-34 PMID: 16524717
  15. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases.
    Am J Pathol. 1998 Sep;153(3):865-73 PMID: 9736035
  16. Altered macrophage differentiation and immune dysfunction in tumor development.
    J Clin Invest. 2007 May;117(5):1155-66 PMID: 17476345
  17. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.
    Immunol Rev. 2008 Apr;222:155-61 PMID: 18364000
  18. A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development.
    FASEB J. 2004 Jan;18(1):161-3 PMID: 14597552
  19. Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis.
    Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3352-7 PMID: 11248082
  20. Helicobacter pylori infection and gastric cancer.
    Best Pract Res Clin Gastroenterol. 2007;21(2):281-97 PMID: 17382277
  21. Inflammation and cancer.
    Nature. 2002 Dec 19-26;420(6917):860-7 PMID: 12490959
  22. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.
    Nature. 2005 Dec 8;438(7069):820-7 PMID: 16341007
  23. Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy?
    Immunol Rev. 2008 Apr;222:222-41 PMID: 18364005
  24. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
    Science. 2008 May 2;320(5876):674-7 PMID: 18403674
  25. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
    Trends Immunol. 2002 Nov;23(11):549-55 PMID: 12401408
  26. Humoral immunity, inflammation and cancer.
    Curr Opin Immunol. 2007 Apr;19(2):209-16 PMID: 17276050
  27. Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases.
    J Control Release. 2007 Nov 6;123(2):123-30 PMID: 17900737
  28. Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase.
    Cancer Res. 2003 Jul 15;63(14):3855-9 PMID: 12873972
  29. The dual effects of interleukin-18 in tumor progression.
    Cell Mol Immunol. 2007 Oct;4(5):329-35 PMID: 17976312
  30. Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions.
    Dig Liver Dis. 2008 Jul;40(7):504-9 PMID: 18486572
  31. Tumor-associated macrophages press the angiogenic switch in breast cancer.
    Cancer Res. 2007 Jun 1;67(11):5064-6 PMID: 17545580
  32. Celecoxib for the prevention of sporadic colorectal adenomas.
    N Engl J Med. 2006 Aug 31;355(9):873-84 PMID: 16943400
  33. Inflammation and cancer: role of nuclear factor-kappaB activation.
    Cancer Sci. 2008 May;99(5):836-42 PMID: 18294278
  34. Nitrosative stress and transcription.
    Biol Chem. 2003 Oct-Nov;384(10-11):1365-77 PMID: 14669980
  35. Tumors and inflammatory infiltrates: friends or foes?
    Clin Exp Metastasis. 2002;19(3):247-58 PMID: 12067205
  36. Mechanisms of angiogenesis.
    Biochemistry (Mosc). 2008 Jul;73(7):751-62 PMID: 18707583
  37. Toll-like receptors in inflammation, infection and cancer.
    Int Immunopharmacol. 2007 Oct;7(10):1271-85 PMID: 17673142
  38. The role of nitric oxide in tumour progression.
    Nat Rev Cancer. 2006 Jul;6(7):521-34 PMID: 16794635
  39. NF-kappaB and the immune response.
    Oncogene. 2006 Oct 30;25(51):6758-80 PMID: 17072327
  40. Inflammation and cancer: is the link as simple as we think?
    J Invest Dermatol. 2005 Jun;124(6):x-xiv PMID: 15955081
  41. Mast cell contribution to angiogenesis related to tumour progression.
    Clin Exp Allergy. 2004 Nov;34(11):1660-4 PMID: 15544587
  42. Association of extracellular cleavage of E-cadherin mediated by MMP-7 with HGF-induced in vitro invasion in human stomach cancer cells.
    Eur Surg Res. 2007;39(4):208-15 PMID: 17396032
  43. CD4+ T cells in cancer stroma, not CD8+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers.
    Cancer Sci. 2003 Nov;94(11):1003-9 PMID: 14611679
  44. New functions for the matrix metalloproteinases in cancer progression.
    Nat Rev Cancer. 2002 Mar;2(3):161-74 PMID: 11990853
  45. Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines.
    Oncogene. 2007 Mar 1;26(10 ):1468-76 PMID: 17001321
  46. Colorectal cancer prevention in ulcerative colitis: a case-control study.
    Aliment Pharmacol Ther. 2000 Feb;14(2):145-53 PMID: 10651654
  47. Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene.
    Nucleic Acids Res. 2004 Apr 23;32(7):2202-13 PMID: 15107488
  48. Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis.
    Exp Biol Med (Maywood). 2006 Jan;231(1):20-7 PMID: 16380641
  49. A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.
    Cancer Res. 2004 Oct 1;64(19):7022-9 PMID: 15466195
  50. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
    N Engl J Med. 1986 Dec 25;315(26):1650-9 PMID: 3537791
  51. Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts.
    Int J Mol Med. 2006 Nov;18(5):941-50 PMID: 17016625
  52. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis.
    Nat Cell Biol. 2006 Dec;8(12):1369-75 PMID: 17128264
  53. Inflammation and cancer: back to Virchow?
    Lancet. 2001 Feb 17;357(9255):539-45 PMID: 11229684
  54. Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer.
    Br J Cancer. 2007 Oct 8;97(7):952-6 PMID: 17848955
  55. Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer.
    Cancer Immunol Immunother. 2009 Mar;58(3):449-59 PMID: 18791714
  56. Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.
    EMBO J. 2008 Jun 18;27(12 ):1671-81 PMID: 18511911
  57. Immune cells as mediators of solid tumor metastasis.
    Cancer Metastasis Rev. 2008 Mar;27(1):11-8 PMID: 18066650
  58. Tumor stroma and regulation of cancer development.
    Annu Rev Pathol. 2006;1:119-50 PMID: 18039110
  59. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
    Nature. 2003 Feb 6;421(6923):639-43 PMID: 12571598
  60. IL-1 is required for tumor invasiveness and angiogenesis.
    Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2645-50 PMID: 12598651
  61. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density.
    Oncol Rep. 2005 Aug;14(2):425-31 PMID: 16012726
  62. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.
    Cancer Res. 2000 Jan 1;60(1):184-90 PMID: 10646872
  63. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
    Nat Med. 1999 Jul;5(7):828-31 PMID: 10395330
  64. Targeting selectins and selectin ligands in inflammation and cancer.
    Expert Opin Ther Targets. 2007 Nov;11(11):1473-91 PMID: 18028011
  65. Nitric oxide-mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen-activated protein kinase.
    Int J Cancer. 2003 Sep 10;106(4):496-504 PMID: 12845643
  66. The interplay between innate and adaptive immunity regulates cancer development.
    Cancer Immunol Immunother. 2005 Nov;54(11):1143-52 PMID: 15889249
  67. The chemokine system in diverse forms of macrophage activation and polarization.
    Trends Immunol. 2004 Dec;25(12):677-86 PMID: 15530839
  68. Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44.
    Immunity. 2007 Apr;26(4):477-489 PMID: 17442598
  69. Cancer and the chemokine network.
    Nat Rev Cancer. 2004 Jul;4(7):540-50 PMID: 15229479
  70. Flow cytometric analysis of Th1 and Th2 cytokines in PBMCs as a parameter of immunological dysfunction in patients of superficial transitional cell carcinoma of bladder.
    Cancer Immunol Immunother. 2006 Jun;55(6):734-43 PMID: 16283306
  71. Cells secreting tumour necrosis factor show enhanced metastasis in nude mice.
    Eur J Cancer. 1990;26(10):1031-4 PMID: 2148875
  72. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma.
    Hepatology. 2007 Jul;46(1):48-57 PMID: 17596875
  73. Oxyradicals and DNA damage.
    Carcinogenesis. 2000 Mar;21(3):361-70 PMID: 10688856
  74. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells.
    Infect Immun. 2005 Apr;73(4):1907-16 PMID: 15784530
  75. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.
    Cancer Res. 2007 Oct 15;67(20):10019-26 PMID: 17942936
  76. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.
    Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):508-13 PMID: 9012814
  77. Inflammation and cancer: an ancient link with novel potentials.
    Int J Cancer. 2007 Dec 1;121(11):2373-80 PMID: 17893866
  78. Candidate genes for the hypoxic tumor phenotype.
    Cancer Res. 2000 Feb 15;60(4):883-7 PMID: 10706099
  79. Human papillomavirus in cervical and head-and-neck cancer.
    Nat Clin Pract Oncol. 2008 Jan;5(1):24-31 PMID: 18097454
  80. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy.
    J Exp Med. 2001 Mar 19;193(6):727-40 PMID: 11257139
  81. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
    Crit Rev Oncol Hematol. 2008 Apr;66(1):1-9 PMID: 17913510
  82. Polarized immune responses differentially regulate cancer development.
    Immunol Rev. 2008 Apr;222:145-54 PMID: 18363999
  83. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution.
    J Cell Biol. 2003 Apr 14;161(1):197-209 PMID: 12695504
Article Info
Journal
Histochemistry and cell biology
Abbr.
Histochem Cell Biol
ISSN
0948-6143
DOI
10.1007/s00418-008-0527-3
Published
2008-12-00
Epub
2008-00-25
Pages
1079-90
Language
English
Region
Germany
NLM ID
9506663
Subset
IM
External Links
PubMed source DOI: 10.1007/s00418-008-0527-3 View journal details
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