Structural basis for exon recognition by a group II intron.
Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.
8 references, click to expand
-
Crystal structure of a self-spliced group II intron.Science. 2008 Apr 4;320(5872):77-82 PMID: 18388288
-
A three-dimensional perspective on exon binding by a group II self-splicing intron.EMBO J. 2000 Sep 15;19(18):5007-18 PMID: 10990464
-
Coevolution of group II intron RNA structures with their intron-encoded reverse transcriptases.RNA. 2001 Aug;7(8):1142-52 PMID: 11497432
-
A second divalent metal ion in the group II intron reaction center.Chem Biol. 2007 Jun;14(6):607-12 PMID: 17584608
-
The two steps of group II intron self-splicing are mechanistically distinguishable.RNA. 1998 Aug;4(8):890-900 PMID: 9701281
-
Introns and the origin of nucleus-cytosol compartmentalization.Nature. 2006 Mar 2;440(7080):41-5 PMID: 16511485
-
Insertion of group II intron retroelements after intrinsic transcriptional terminators.Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6620-5 PMID: 17420455
-
Retroids in archaea: phylogeny and lateral origins.Mol Biol Evol. 2003 Jul;20(7):1134-42 PMID: 12777534
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